About: Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo
Creator	Cho, Won-Kyung Lee, Jong-Soo Kim, Tae-Hwan Kim, Jae-Hoon Chathuranga, Kiramage Lee, Hyun-Cheol Ekanayaka, Pathum Kim, Hong Ma, Jin Chathuranga, W Kim, Myun Wijerathne, H
Source	PMC
abstract	The herbs Plantago asiatica and Clerodendrum trichotomum have been commonly used for centuries in indigenous and folk medicine in tropical and subtropical regions of the world. In this study, we show that extracts from these herbs have antiviral effects against the respiratory syncytial virus (RSV) in vitro cell cultures and an in vivo mouse model. Treatment of HEp2 cells and A549 cells with a non-cytotoxic concentration of Plantago asiatica or Clerodendrum trichotomum extract significantly reduced RSV replication, RSV-induced cell death, RSV gene transcription, RSV protein synthesis, and also blocked syncytia formation. Interestingly, oral inoculation with each herb extract significantly improved viral clearance in the lungs of BALB/c mice. Based on reported information and a high-performance liquid chromatography (HPLC) analysis, the phenolic glycoside acteoside was identified as an active chemical component of both herb extracts. An effective dose of acteoside exhibited similar antiviral effects as each herb extract against RSV in vitro and in vivo. Collectively, these results suggest that extracts of Plantago asiatica and Clerodendrum trichotomum could provide a potent natural source of an antiviral drug candidate against RSV infection.
has issue date	2019-07-03(xsd:dateTime)
bibo:doi	10.3390/v11070604
bibo:pmid	31277257
has license	cc-by
sha1sum (hex)	d8d257c7faebdd3d749b56befc9927d7d064e512
schema:url	https://doi.org/10.3390/v11070604
resource representing a document's title	Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo
has PubMed Central identifier	PMC6669655
has PubMed identifier	31277257
schema:publication	Viruses
resource representing a document's body	covid:d8d257c7faebdd3d749b56befc9927d7d064e512#body_text
is schema:about of	named entity 'Treatment' named entity 'Plantago' named entity 'acteoside' named entity 'improved' named entity 'extracts' named entity 'Activity' named entity 'HAVE' named entity 'ACTEOSIDE' named entity 'MICE' named entity 'CYTOTOXIC' named entity 'HERBS' named entity 'PROVIDE' named entity 'EFFECTIVE DOSE' named entity 'VIRAL CLEARANCE' named entity 'TROPICAL' named entity 'NATURAL SOURCE' named entity 'BALB' named entity 'ANTIVIRAL DRUG' named entity 'CELL CULTURES' named entity 'TREATMENT' named entity 'LIQUID CHROMATOGRAPHY ' named entity 'ACTIVE' named entity 'PROTEIN SYNTHESIS' named entity 'GENE TRANSCRIPTION' named entity 'CELLS' named entity 'REDUCED' named entity 'SIMILAR' named entity 'WORLD' named entity 'CENTURIES' named entity 'THE LUNGS' named entity 'CELL DEATH' named entity 'EXTRACTS' named entity 'HERB' named entity 'PLANTAGO ASIATICA' named entity 'PLANTAGO ASIATICA' named entity 'CANDIDATE' named entity 'RSV' named entity 'SUGGEST' named entity 'INFORMATION' named entity 'IN VITRO' named entity 'EXTRACT' named entity 'MOUSE MODEL' covid:arg/d8d257c7faebdd3d749b56befc9927d7d064e512 named entity 'BASED' named entity 'CLERODENDRUM TRICHOTOMUM' named entity 'HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY' named entity 'IN VIVO' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'EXTRACTS' named entity 'ACTIVITY' named entity 'IN VITRO' named entity 'CLERODENDRUM TRICHOTOMUM' named entity 'IN VIVO' named entity 'RSV INFECTION' named entity 'FOLK MEDICINE' named entity 'FORMATION' named entity 'INOCULATION' named entity 'REPLICATION' named entity 'A549 CELLS' named entity 'THESE' named entity 'STUDY' named entity 'PHENOLIC GLYCOSIDE' named entity 'CONCENTRATION OF' named entity 'ANALYSIS' named entity 'USED' named entity 'RESULTS' named entity 'EFFECTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'IDENTIFIED' named entity 'INDIGENOUS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software