About: Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
Creator	Huang, Jian Su, Jing Min, Jun Xu, Anlong Chen, Shangwu Duan, Zhaohui Lan, Dongming Liu, Zehuan Shao, Hongwei Zhang, Lichun
source	Medline; PMC
abstract	The observations that Lymphopenia is common in severe acute respiratory syndrome (SARS) patients and that peripheral blood mononuclear cell (PBMC) could be infected by SARS-CoV indicate that PBMC could be useful in identifying the gene expression profile in convalescent patients and tracing the host response to SARS-CoV infection. In this study, the altered genes expressions in the PBMC of convalescent SARS patients were investigated with suppression subtractive hybridization (SSH). We found that genes encoded by mitochondrial DNA (mtDNA) were obviously upregulated, while mitochondria were now found to be closely connected with antiviral immunity. The identification of a viral gene, M, in SSH cDNA library shows the long-term existence of SARS-CoV in vivo. In addition, some oxidative stress sensitive genes, heat shock proteins, transcription factors, and cytokines showed remarkable elevation. Thin-section electron microscope shows increased lysosome-like granule and mitochondria in PBMC of patients. These results provide important intracellular clue for tracing host response to SARS-CoV infection and suggest a role of mitochondria in that process.
has issue date	2006-10-06(xsd:dateTime)
bibo:doi	10.1007/s10875-006-9046-y
bibo:pmid	17024565
has license	no-cc
sha1sum (hex)	d90d824ebfd4ffc8c3045571391e41dcceedb420
schema:url	https://doi.org/10.1007/s10875-006-9046-y
resource representing a document's title	Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients
has PubMed Central identifier	PMC7086694
has PubMed identifier	17024565
schema:publication	J Clin Immunol
resource representing a document's body	covid:d90d824ebfd4ffc8c3045571391e41dcceedb420#body_text
is schema:about of	named entity 'expressions' named entity 'SSH' named entity 'mtDNA' named entity 'oxidative stress' named entity 'electron microscope' named entity 'sensitive' named entity 'convalescent' named entity 'MITOCHONDRIAL GENE EXPRESSION' named entity 'IMMUNITY' named entity 'IDENTIFICATION' named entity 'SECTION' named entity 'PROVIDE' named entity 'GRANULE' named entity 'IDENTIFYING' named entity 'USEFUL' named entity 'IMPORTANT' named entity 'MITOCHONDRIAL DNA' named entity 'ADDITION' named entity 'STUDY' named entity 'COULD BE' named entity 'SUPPRESSION SUBTRACTIVE HYBRIDIZATION' named entity 'THESE' named entity 'MITOCHONDRIA' named entity 'INVESTIGATED' named entity 'CYTOKINES' named entity 'OBSERVATIONS' named entity 'LONG-TERM' named entity 'SARS' named entity 'PBMC' named entity 'SARS' covid:arg/d90d824ebfd4ffc8c3045571391e41dcceedb420 named entity 'PATIENTS' named entity 'PBMC' named entity 'ANTIVIRAL' named entity 'ROLE' named entity 'RESULTS' named entity 'FOUND' named entity 'LYSOSOME' named entity 'PATIENTS' named entity 'CONVALESCENT' named entity 'ENCODED' named entity 'PROCESS' named entity 'GENES' named entity 'OXIDATIVE STRESS' named entity 'GENE EXPRESSION PROFILE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ALTERED' named entity 'CONVALESCENT' named entity 'SUGGEST' named entity 'INFECTED' named entity 'UPREGULATION' named entity 'SARS-COV' named entity 'COMMON' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELL' named entity 'HEAT SHOCK PROTEINS' named entity 'EXPRESSIONS' named entity 'INCREASED' named entity 'SENSITIVE' named entity 'ELEVATION' named entity 'UPREGULATED' named entity 'ELECTRON MICROSCOPE' named entity 'LYMPHOPENIA' named entity 'SSH' named entity 'CDNA LIBRARY' named entity 'VIRAL GENE' named entity 'IN VIVO' named entity 'LIKE' named entity 'TRANSCRIPTION FACTORS' named entity 'INTRACELLULAR' named entity 'viral' named entity 'mitochondria' named entity 'tracing'

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