About: Early IFN type I response: Learning from microbial evasion strategies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Early IFN type I response: Learning from microbial evasion strategies
Creator	Battistini, A Coccia, E
source	Elsevier; Medline; PMC
abstract	Abstract Type I interferon (IFN) comprises a class of cytokines first discovered more than 50 years ago and initially characterized for their ability to interfere with viral replication and restrict locally viral propagation. As such, their induction downstream of germ-line encoded pattern recognition receptors (PRRs) upon recognition of pathogen-associated molecular patterns (PAMPs) is a hallmark of the host antiviral response. The acknowledgment that several PAMPs, not just of viral origin, may induce IFN, pinpoints at these molecules as a first line of host defense against a number of invading pathogens. Acting in both autocrine and paracrine manner, IFN interferes with viral replication by inducing hundreds of different IFN-stimulated genes with both direct anti-pathogenic as well as immunomodulatory activities, therefore functioning as a bridge between innate and adaptive immunity. On the other hand an inverse interference to escape the IFN system is largely exploited by pathogens through a number of tactics and tricks aimed at evading, inhibiting or manipulating the IFN pathway, that result in progression of infection or establishment of chronic disease. In this review we discuss the interplay between the IFN system and some selected clinically important and challenging viruses and bacteria, highlighting the wide array of pathogen-triggered molecular mechanisms involved in evasion strategies.
has issue date	2015-03-31(xsd:dateTime)
bibo:doi	10.1016/j.smim.2015.03.005
bibo:pmid	25869307
has license	els-covid
sha1sum (hex)	d931dcba5e7ae4361afc140d8d80920285edc264
schema:url	https://doi.org/10.1016/j.smim.2015.03.005
resource representing a document's title	Early IFN type I response: Learning from microbial evasion strategies
has PubMed Central identifier	PMC7129383
has PubMed identifier	25869307
schema:publication	Seminars in Immunology
resource representing a document's body	covid:d931dcba5e7ae4361afc140d8d80920285edc264#body_text
is schema:about of	named entity 'inhibiting' named entity 'hallmark' named entity 'viral' named entity 'The' named entity 'innate' named entity 'EARLY' named entity 'STRATEGIES' named entity 'GENES' named entity 'INTERFERON ' named entity 'NUMBER OF' named entity 'DOWNSTREAM' named entity 'VIRAL' named entity 'IMMUNOMODULATORY' named entity 'INDUCING' named entity 'LINE' named entity 'A CLASS' named entity 'MANIPULATING' named entity 'ACTIVITIES' named entity 'DIRECT' named entity 'PROGRESSION' named entity 'SYSTEM' named entity 'ASSOCIATED' named entity 'JUST' named entity 'INFECTION' named entity 'RESTRICT' named entity 'PATHOGEN' named entity 'PAMPS' named entity 'MICROBIAL' named entity 'LEARNING' named entity 'FUNCTIONING' named entity 'INTERFERENCE' named entity 'INHIBITING' named entity 'THEIR' named entity 'INDUCE' named entity 'DIFFERENT' named entity 'MOLECULAR' named entity 'HAND' named entity 'ESCAPE' named entity 'CHARACTERIZED' named entity 'GERM' named entity 'CHRONIC DISEASE' named entity 'INTERFERES WITH' named entity 'RECOGNITION' named entity 'RESULT' named entity 'INDUCTION' named entity 'STIMULATED' named entity 'HOST DEFENSE' named entity 'YEARS' named entity 'LARGELY' named entity 'ANTIVIRAL RESPONSE' named entity 'PATHWAY' named entity 'HOST' named entity 'INVERSE' named entity 'PATHOGENIC' named entity 'MOLECULES' named entity 'IS A' named entity 'LOCALLY' named entity 'PATHOGENS' named entity 'TRICKS' named entity 'ESTABLISHMENT' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'MORE THAN 50' named entity 'THESE' named entity 'IFN' named entity 'INTERFERE' named entity 'ORIGIN' named entity 'TYPE I INTERFERON' named entity 'ADAPTIVE IMMUNITY' named entity 'PATTERNS' named entity 'CYTOKINES' named entity 'BRIDGE' named entity 'PARACRINE' named entity 'INITIALLY' named entity 'AUTOCRINE' named entity 'ENCODED' named entity 'VIRAL REPLICATION' named entity 'AGO' named entity 'IFN TYPE I' named entity 'RESPONSE' named entity 'PROPAGATION'

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