About: Modulation of immunity and inflammatory gene expression in buffalo (Bubalus bubalis) with some digestive disorders

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About: Modulation of immunity and inflammatory gene expression in buffalo (Bubalus bubalis) with some digestive disorders Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Modulation of immunity and inflammatory gene expression in buffalo (Bubalus bubalis) with some digestive disorders
Creator	El-Ashker, Maged Ouda, Mohamed Youssef, Mohamed
Source	Medline; PMC
abstract	So far, there has been scarce information about the status of immunoglobulins (Ig) and the gene expression of inflammatory cytokines in buffaloes showing digestive troubles. The purpose of the present study was to explore the modulation of gene expression of some immune-inflammatory markers in buffaloes suffered from various digestive disorders. For this reason, 50 native breed water buffaloes were studied. Forty of these buffaloes showed various symptoms of digestive disorders and were allocated into 4 groups of equal sizes (group 1: uncategorized stomatitis; group 2: acute traumatic reticuloperitonitis [TRR]; group 3: acute rumen impaction; and group 4: undifferentiated enteritis). Ten apparently healthy buffaloes were randomly selected and considered as a control group. RNA was firstly extracted from the whole blood then a reverse transcription kits was used to convert the RNA to cDNA. Real-time PCR was used to measure the expression of mRNAs of interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor (TNF)-α, IgG, and IgA, while glyceraldehyde-3-phosphate dehydrogenase (GAPDH) used as an internal reference. The results of real-time PCR revealed a significant (P ≤ 0.05) upregulation of the gene expression of IL-1β, IL-6, IL-10, and TNF-α in blood of diseased buffaloes compared with those of controls. Animals showing acute TRP had peak values of both IL-6 and IL-10; while those exhibiting enteritis and rumen impaction had the highest values of IL-1β and TNF-α, respectively. The results of qPCR also revealed a significant (P ≤ 0.05) downregulation of both IgG and IgA gene expression in blood of all diseased buffaloes compared with controls. The lowest values of both genes were recorded in buffaloes showing acute TRP. The results herein suggest that the tested genes could have a pivotal role in the pathophysiologic mechanism of the underlying diseases.
has issue date	2017-05-31(xsd:dateTime)
bibo:doi	10.1007/s00580-017-2496-1
bibo:pmid	32214977
has license	no-cc
sha1sum (hex)	d9787532327b1e5359931979e879b9eb1ee58ad0
schema:url	https://doi.org/10.1007/s00580-017-2496-1
resource representing a document's title	Modulation of immunity and inflammatory gene expression in buffalo (Bubalus bubalis) with some digestive disorders
has PubMed Central identifier	PMC7088432
has PubMed identifier	32214977
schema:publication	Comp Clin Path
resource representing a document's body	covid:d9787532327b1e5359931979e879b9eb1ee58ad0#body_text
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