About: CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral infection

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About: CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral infection
Creator	Dittmer, Ulf Zhou, Fan Zelinskyy, Gennadiy Hardt, Cornelia Duhan, Vikas Khairnar, Vishal Sharma, Piyush Göthert, Joachim Lang, Karl Lang, Philipp Singer, Bernhard Westendorf, Astrid Bhat, Hilal Adomati, Tom Bezgovsek, Judith Dreesen, Janine Friendrich, Sarah-Kim Patil, Ashwini Thoens, Christine Timm, Jörg Wennemuth, Gunther
Source	PMC
abstract	Dysfunction of CD8(+) T cells can lead to the development of chronic viral infection. Identifying mechanisms responsible for such T cell dysfunction is therefore of great importance to understand how to prevent persistent viral infection. Here we show using lymphocytic choriomeningitis virus (LCMV) infection that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is fundamental for recruiting lymphocyte-specific protein kinase (Lck) into the T cell receptor complex to form an efficient immunological synapse. CEACAM1 is essential for activation of CD8(+) T cells, and the absence of CEACAM1 on virus-specific CD8(+) T cells limits the antiviral CD8(+) T cell response. Treatment with anti-CEACAM1 antibody stabilizes Lck in the immunological synapse, prevents CD8(+) T cell exhaustion, and improves control of virus infection in vivo. Treatment of human virus-specific CD8(+) T cells with anti-CEACAM1 antibody similarly enhances their proliferation. We conclude that CEACAM1 is an important regulator of virus-specific CD8(+) T cell functions in mice and humans and represents a promising therapeutic target for modulating CD8(+) T cells.
has issue date	2018-07-02(xsd:dateTime)
bibo:doi	10.1038/s41467-018-04832-2
bibo:pmid	29967450
has license	cc-by
sha1sum (hex)	d9b9b75ee4d554ad43e8a8531af0b6763a1d6652
schema:url	https://doi.org/10.1038/s41467-018-04832-2
resource representing a document's title	CEACAM1 promotes CD8(+) T cell responses and improves control of a chronic viral infection
has PubMed Central identifier	PMC6028648
has PubMed identifier	29967450
schema:publication	Nat Commun
resource representing a document's body	covid:d9b9b75ee4d554ad43e8a8531af0b6763a1d6652#body_text
is schema:about of	named entity 'CHRONIC' named entity 'functions' named entity 'CD8' named entity 'mechanisms' named entity 'exhaustion' named entity 'immunological synapse' named entity 'vivo' named entity 'CD8' named entity 'virus' named entity 'protein kinase' named entity 'response' named entity 'CD8' named entity 'chronic' named entity 'IMPROVES' named entity 'MICE' named entity 'IMPORTANT' named entity 'PROTEIN KINASE' named entity 'EXHAUSTION' named entity 'CONCLUDE' named entity 'CD8' named entity 'INFECTION' named entity 'DYSFUNCTION' named entity 'ESSENTIAL' named entity 'SPECIFIC' named entity 'DEVELOPMENT' named entity 'RESPONSIBLE' named entity 'PERSISTENT' named entity 'HUMANS' named entity 'T CELLS' named entity 'LEAD' named entity 'T CELL DYSFUNCTION' named entity 'IN VIVO' named entity 'RESPONSES' named entity 'CEACAM1' named entity 'PREVENTS' named entity 'CHRONIC' named entity 'UNDERSTAND' named entity 'TO FORM' named entity 'USING' named entity 'CELL FUNCTIONS' named entity 'RECRUITING' named entity 'LIMITS' named entity 'TO PREVENT' named entity 'HUMAN VIRUS' named entity 'T CELL RESPONSE' named entity 'TREATMENT' named entity 'LCK' named entity 'IDENTIFYING' named entity 'VIRUS' named entity 'HOW' named entity 'CD8' named entity 'REGULATOR' named entity 'ANTIVIRAL' named entity 'THERAPEUTIC TARGET' named entity 'VIRAL INFECTION' named entity 'ACTIVATION' named entity 'IMPROVES' named entity 'GREAT' named entity 'CONTROL' named entity 'CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1' named entity 'CONTROL'

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