About: Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt

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About: Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt
Creator	El-Deeb, Ayman El-Kady, Magdy Paldurai, Anandan Zouelfakkar, Sahar Abozeid, Hassanein Afifi, Manal Khattar, Sunil Samal, Siba Varghese, Berin
Source	Medline; PMC
abstract	Infectious bronchitis virus (IBV) causes a major disease problem for the poultry industry worldwide. The currently used live-attenuated vaccines have the tendency to mutate and/or recombine with circulating field strains resulting in the emergence of vaccine-derived variant viruses. In order to circumvent these issues, and to develop a vaccine that is more relevant to Egypt and its neighboring countries, a recombinant avirulent Newcastle disease virus (rNDV) strain LaSota was constructed to express the codon-optimized S glycoprotein of the Egyptian IBV variant strain IBV/Ck/EG/CU/4/2014 belonging to GI-23 lineage, that is prevalent in Egypt and in the Middle East. A wild type and two modified versions of the IBV S protein were expressed individually by rNDV. A high level of S protein expression was detected in vitro by Western blot and immunofluorescence analyses. All rNDV-vectored IBV vaccine candidates were genetically stable, slightly attenuated and showed growth patterns comparable to that of parental rLaSota virus. Single-dose vaccination of 1-day-old SPF White Leghorn chicks with the rNDVs expressing IBV S protein provided significant protection against clinical disease after IBV challenge but did not show reduction in tracheal viral shedding. Single-dose vaccination also provided complete protection against virulent NDV challenge. However, prime-boost vaccination using rNDV expressing the wild type IBV S protein provided better protection, after IBV challenge, against clinical signs and significantly reduced tracheal viral shedding. These results indicate that the NDV-vectored IBV vaccines are promising bivalent vaccine candidates to control both infectious bronchitis and Newcastle disease in Egypt. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13567-019-0631-5) contains supplementary material, which is available to authorized users.
has issue date	2019-02-11(xsd:dateTime)
bibo:doi	10.1186/s13567-019-0631-5
bibo:pmid	30744668
has license	cc-by
sha1sum (hex)	d9c174a11b8d2bd0a4df65b17e576934f3cce31c
schema:url	https://doi.org/10.1186/s13567-019-0631-5
resource representing a document's title	Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt
has PubMed Central identifier	PMC6371441
has PubMed identifier	30744668
schema:publication	Vet Res
resource representing a document's body	covid:d9c174a11b8d2bd0a4df65b17e576934f3cce31c#body_text
is schema:about of	named entity 'disease' named entity 'recombine' named entity 'develop' named entity 'disease' named entity 'DEVELOPMENT' named entity 'VACCINE' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'ITS' covid:arg/d9c174a11b8d2bd0a4df65b17e576934f3cce31c named entity 'ATTENUATED' named entity 'STABLE' named entity 'S PROTEIN' named entity 'VIRULENT' named entity 'PARENTAL' named entity 'RECOMBINANT' named entity 'CIRCULATING' named entity 'BETTER' named entity 'EGYPT' named entity 'PROTEIN ' named entity 'CODON' named entity 'PROVIDED' named entity 'TENDENCY' named entity 'DETECTED' named entity 'MUTATE' named entity 'PROBLEM' named entity 'USING' named entity 'RESULTING IN' named entity 'AVIRULENT' named entity 'USED' named entity 'INFECTIOUS BRONCHITIS' named entity 'STRAIN' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'VECTORED' named entity 'VARIANT' named entity 'STRAINS' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'RECOMBINANT' named entity 'NEIGHBORING' named entity 'SIGNIFICANT' named entity 'VIRAL SHEDDING' named entity 'TRACHEAL' named entity 'BOOST VACCINATION' named entity 'POULTRY INDUSTRY' named entity 'REDUCTION' named entity 'STRAINS' named entity 'CURRENTLY' named entity 'ISSUES' named entity 'HAVE' named entity 'SINGLE' named entity 'PREVALENT' named entity 'RELEVANT' named entity 'LIVE' named entity 'EXPRESSED' named entity 'THESE' named entity 'CLINICAL' named entity 'WORLDWIDE' named entity 'DERIVED' named entity 'LINEAGE' named entity 'COUNTRIES' named entity 'COMPLETE' named entity 'MIDDLE EAST' named entity 'VECTORED' named entity 'TO CONTROL' named entity 'VIRUS' named entity 'ATTENUATED VACCINES' named entity 'TO EXPRESS' named entity 'VIRUSES' named entity 'EMERGENCE' named entity 'IMMUNOFLUORESCENCE' named entity 'DOSE' named entity 'WHITE LEGHORN' named entity 'GLYCOPROTEIN' named entity 'MODIFIED'

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