About: Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes
Creator	Fink, Colin Gormley, Stuart Kaforou, Myrsini Levin, Michael Martinon-Torres, Federico Montana, Giovanni Patel, Sanjay Paulus, Stéphane Herberg, Jethro Sumner, Edward Jones, Kelsey Wright, Victoria
source	Medline; PMC
abstract	We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
has issue date	2013-07-29(xsd:dateTime)
bibo:doi	10.1093/infdis/jit348
bibo:pmid	23901082
has license	bronze-oa
sha1sum (hex)	d9d57e6e5eaf077c1223b5295b461b7f2f1cfc82
schema:url	https://doi.org/10.1093/infdis/jit348
resource representing a document's title	Transcriptomic Profiling in Childhood H1N1/09 Influenza Reveals Reduced Expression of Protein Synthesis Genes
has PubMed Central identifier	PMC3805235
has PubMed identifier	23901082
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:d9d57e6e5eaf077c1223b5295b461b7f2f1cfc82#body_text
is schema:about of	named entity 'GENES' named entity 'PROTEIN SYNTHESIS' named entity 'INFLUENZA' named entity 'protein synthesis' named entity 'response' named entity 'EXPRESSION' named entity 'ADAPTIVE' named entity 'MOST SIGNIFICANT' named entity 'INDEPENDENT' named entity 'TRANSCRIPTOME' named entity 'PROTEIN SYNTHESIS' named entity 'DISTINGUISHING' named entity 'PATHWAY' named entity 'EXPRESSION PROFILE' named entity 'CHARACTERIZED' named entity 'INFLUENZA A' named entity 'RESPIRATORY SYNCYTIAL VIRUS' covid:arg/d9d57e6e5eaf077c1223b5295b461b7f2f1cfc82 named entity 'H1N1' named entity 'EXPRESSION' named entity 'BLOOD' named entity 'REDUCED' named entity 'RESPONSE' named entity 'REDUCED' named entity 'CHILDHOOD' named entity 'REVEALS' named entity 'GENES' named entity 'BACTERIAL INFECTION' named entity 'RNA' named entity 'CHILDREN HOSPITALIZED' named entity 'FUNCTION' named entity 'INFLAMMATORY' named entity 'VALIDATED' named entity 'COMPARED' named entity 'HEALTHY' named entity 'RSV' named entity 'COHORT' named entity 'IMMUNE' named entity 'IS A' named entity 'PATIENTS' named entity 'COMPONENT' named entity 'INFECTION' named entity 'CHILDREN' named entity 'INCREASED EXPRESSION' named entity 'H1N1' named entity 'KEY' named entity 'REDUCED GENE EXPRESSION' named entity 'expression' named entity 'validated' named entity 'genes' named entity 'gene' named entity 'cohort' named entity 'compared' named entity 'H1N1/09' named entity 'patients' named entity 'compared' named entity 'protein synthesis' named entity 'transcriptome' named entity 'H1N1/09' named entity 'H1N1/09' named entity 'RNA' named entity 'Transcriptomic' named entity 'H1N1/09' named entity 'Influenza' named entity 'Protein Synthesis' named entity 'upregulated' named entity 'bacterial DNA' named entity 'interferon' named entity 'immunopathogenesis' named entity 'protein synthesis'

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