About: A universal microarray for detection of SARS coronavirus

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About: A universal microarray for detection of SARS coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A universal microarray for detection of SARS coronavirus
Creator	Zhao, Guo-Ping Liu, Jian-Hua Gu, Xiao-Mei Long, Wei-Hong Xiao, Hua-Sheng Yang, Hong-Jun Zhang, Qing-Hua
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SARS-CoV). There are many point mutations among SARS-CoV genome sequences. Previous studies suggested that the mutations are correlated closely with the SARS epidemic. It was found that the bases of six nucleotide positions (nt9404, nt9479, nt19838, nt21721, nt22222 and nt27827) with high-mutation rate have an important relationship with the SARS epidemic. For viral detection as well as genotyping, a universal microarray system was developed that combines RT-PCR and ligase detection reaction (LDR). The Zip Codes attached covalently to a slide remain constant and their complementary Zip Codes (cZip Codes) can be used for tagging target sequence, making the microarrays universal. The discriminating oligonucleotides contain on the 5′ end “cZip Codes” that are used to direct LDR product to specific Zip Codes attached covalently to a slide. Since Zip Codes have no homology to either the target sequence or to other sequences in the genomes of both human host and SARS-CoV, there was no false signal due to mismatch hybridizations. 20 samples assayed with the universal microarray were confirmed by DNA sequencing, demonstrating that this microarray system is a promising diagnostic tool for detection and genotyping of the SARS-CoV.
has issue date	2004-10-31(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2004.06.016
bibo:pmid	15350733
has license	els-covid
sha1sum (hex)	d9efbc0272aa40251062b97b94ee330f4fd50a05
schema:url	https://doi.org/10.1016/j.jviromet.2004.06.016
resource representing a document's title	A universal microarray for detection of SARS coronavirus
has PubMed Central identifier	PMC7112900
has PubMed identifier	15350733
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:d9efbc0272aa40251062b97b94ee330f4fd50a05#body_text
is schema:about of	named entity 'tagging' named entity 'sequences' named entity 'detection' covid:arg/d9efbc0272aa40251062b97b94ee330f4fd50a05 named entity 'HAVE' named entity 'UNIVERSAL' named entity 'TO DIRECT' named entity 'CORRELATED' named entity 'HUMAN' named entity 'TARGET' named entity 'CONSTANT' named entity 'CONFIRMED BY' named entity 'GENOTYPING' named entity 'END' named entity 'POINT MUTATIONS' named entity 'ZIP' named entity 'MUTATION RATE' named entity 'SAMPLES' named entity 'NUCLEOTIDE' named entity 'CAUSED BY' named entity 'DETECTION' named entity 'COMBINES' named entity 'FALSE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'CONTAIN' named entity 'PRODUCT' named entity 'SARS CORONAVIRUS' named entity 'HOST' named entity 'UNIVERSAL' named entity 'SARS CORONAVIRUS' named entity 'MICROARRAYS' named entity 'OTHER SEQUENCES' named entity 'RT-PCR' named entity 'PREVIOUS' named entity 'FOUND' named entity 'EPIDEMIC' named entity 'SLIDE' named entity 'MICROARRAY' named entity 'USED' named entity 'DETECTION' named entity 'SEQUENCE' named entity 'DNA SEQUENCING' named entity 'DIAGNOSTIC TOOL' named entity 'IS A' named entity 'ATTACHED' named entity 'POSITIONS' named entity 'TAGGING' named entity 'MICROARRAY' named entity 'DUE TO' named entity 'EITHER' named entity 'VIRAL DETECTION' named entity 'OLIGONUCLEOTIDES' named entity 'THEIR' named entity 'MISMATCH' named entity 'BASES' named entity 'HIGH' named entity 'SIGNAL' named entity 'SARS' named entity 'SEQUENCES' named entity 'CODES' named entity 'HOMOLOGY' named entity 'SPECIFIC' named entity 'GENOMES' named entity 'STUDIES' named entity 'MUTATIONS' named entity 'LIGASE DETECTION REACTION' named entity 'SYSTEM' named entity 'sequence' named entity 'Codes' named entity 'LDR' named entity 'assayed' named entity 'point mutations' named entity 'sequences' named entity 'specific' named entity 'suggested'

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