About: Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy
Creator	Benites, Eliana Berezin, Eitan Cabrini, Dayane Cardoso G E Saulo, Maria Catalan, Daniel Passos, D Silva, Andrea Silva, Juliana
Source	Elsevier; PMC
abstract	Abstract Objective to estimate the prevalence of infection by respiratory viruses in pediatric patients with cancer and acute respiratory infection (ARI) and/or fever. Methods cross‐sectional study, from January 2011 to December 2012. The secretions of nasopharyngeal aspirates were analyzed in children younger than 21 years with acute respiratory infections. Patients were treated at the Grupo em Defesa da Criança Com Câncer (Grendacc) and University Hospital (HU), Jundiaí, SP. The rapid test was used for detection of influenza virus (Kit Biotrin, Inc. Ireland), and real‐time multiplex polymerase chain reaction (FTD, Respiratory pathogens, multiplex Fast Trade Kit, Malta) for detection of influenza virus (H1N1, B), rhinovirus, parainfluenza virus, adenovirus, respiratory syncytial virus, human parechovirus, bocavirus, metapneumovirus, and human coronavirus. The prevalence of viral infection was estimated and association tests were used (χ2 or Fisher's exact test). Results 104 samples of nasopharyngeal aspirate and blood were analyzed. The median age was 12 ± 5.2 years, 51% males, 68% whites, 32% had repeated ARIs, 32% prior antibiotic use, 19.8% cough, and 8% contact with ARIs. A total of 94.3% were in good general status. Acute lymphocytic leukemia (42.3%) was the most prevalent neoplasia. Respiratory viruses were detected in 50 samples: rhinoviruses (23.1%), respiratory syncytial virus AB (8.7%), and coronavirus (6.8%). Co‐detection occurred in 19% of cases with 2 viruses and in 3% of those with 3 viruses, and was more frequent between rhinovirus and coronavirus 43. Fever in neutropenic patients was observed in 13%, of which four (30.7) were positive for viruses. There were no deaths. Conclusions the prevalence of respiratory viruses was relevant in the infectious episode, with no increase in morbidity and mortality. Viral co‐detection was frequent in patients with cancer and ARIs. Resumo Objetivo estimar a prevalência da infecção pelos vírus respiratórios em pacientes pediátricos com câncer e infecção respiratória aguda (IRA) e/ou febre. Métodos estudo transversal, de janeiro de 2011 a dezembro de 2012. Foram analisadas secreções de aspirado da nasofaringe de menores de 21 anos, com quadro respiratório agudo, atendidos nos hospitais Grendacc e HU, Jundiaí, SP. Foi aplicado o teste rápido para detecção dos vírus influenza (Kit Biotrin®) e a reação em cadeia da polimerase multiplex em tempo real (Kit multiplex/Fast Trade®) para detecção dos vírus: influenza (A, H1N1, B), rinovírus, parainfluenza, adenovírus respiratório, vírus respiratório sincicial, parechovírus, bocavírus, metapneumovírus humano e coronavírus humano. Foi estimada a prevalência de infecção viral e usados testes de associação (χ2 ou teste exato de Fisher). Resultados foram analisadas 104 amostras de aspirado de nasofaringe e sangue. A mediana para a idade foi 12±5,2 anos; masculino (51%); cor branca (68%); IVAS de repetição (32%); uso prévio de antibiótico (32%); tosse (19,8%); e contato com IVAS (8%). Apresentavam‐se em bom estado geral 94,3% dos pacientes. A leucemia linfocítica aguda (42,3%) foi mais prevalente. Foram detectados vírus respiratórios em 50% das amostras: rinovírus (23,1%), vírus sincicial respiratório A/B (8,7%) e coronavírus (6,8%). Ocorreu codetecção em 19% entre dois vírus, e de 3% entre três vírus, sendo a mais frequente entre rinovírus e coronavírus 43. Febre em neutropênicos foi de 13%, sendo quatro (30,7%) com vírus positivo. Não houve óbitos. Conclusões a prevalência de vírus respiratórios foi importante no episódio infeccioso, sem aumento da morbimortalidade. As codetecções foram frequentes em pacientes com câncer e IRA.
has issue date	2014-08-31(xsd:dateTime)
bibo:doi	10.1016/j.jpedp.2014.01.004
has license	els-covid
sha1sum (hex)	da3c13d431db06ed31f0a34985d0f1a24f189406
schema:url	https://doi.org/10.1016/j.jpedp.2014.01.004
resource representing a document's title	Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy
has PubMed Central identifier	PMC7153729
schema:publication	Jornal de Pediatria (Versão em Português)
resource representing a document's body	covid:da3c13d431db06ed31f0a34985d0f1a24f189406#body_text
is schema:about of	named entity 'RESPIRATORY VIRUSES' named entity 'ANTIBIOTIC USE' named entity 'FEVER' named entity 'PRIOR' named entity 'TRADE' named entity 'BOCAVIRUS' named entity 'COM' named entity 'MALES' named entity 'ASPIRATES' named entity 'ANALYZED' named entity 'USED' named entity 'DETECTION' named entity 'REPEATED' named entity 'VIRAL INFECTION' named entity 'GENERAL STATUS' named entity 'MEDIAN' named entity 'ACUTE RESPIRATORY INFECTION' named entity 'MULTIPLEX POLYMERASE CHAIN REACTION' named entity 'DOI' named entity 'nasopharyngeal' named entity 'fever' named entity 'adenovirus' named entity 'multiplex' named entity 'aspirates' named entity 'Kit' named entity 'prevalence' named entity 'Acute' named entity 'KIT' named entity 'RAPID' named entity 'UNIVERSITY HOSPITAL' named entity 'WHITES' named entity 'DECEMBER' named entity '104' named entity 'RESULTS' named entity 'PEDIATRIC' named entity 'ACUTE' named entity 'NASOPHARYNGEAL' named entity 'CONTACT WITH' named entity 'SAMPLES' named entity 'OBJECTIVE' named entity 'CROSS-SECTIONAL STUDY' named entity 'FISHER' named entity 'TREATED' named entity 'ACUTE' named entity 'RHINOVIRUS' named entity 'PARAINFLUENZA VIRUS' named entity 'HTTP' named entity 'TOTAL' named entity 'ASSOCIATION' named entity 'ESTIMATE' named entity 'CHILDREN' named entity 'PEDIATRIC CANCER' named entity 'PATIENTS' named entity 'VIRAL INFECTIONS' named entity 'CHEMOTHERAPY' named entity 'METHODS' named entity 'FAST' named entity 'IRELAND' named entity 'MULTIPLEX' named entity 'LYMPHOCYTIC' named entity 'GOOD' named entity 'ESTIMATED' named entity 'BLOOD' named entity 'GRUPO' named entity 'COUGH' named entity 'METAPNEUMOVIRUS' named entity 'RESPIRATORY' named entity 'AGE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'YOUNGER' named entity 'HUMAN PARECHOVIRUS' named entity 'YEARS' named entity 'PATIENTS' named entity 'REAL-TIME' named entity 'INFLUENZA VIRUS' named entity 'SECRETIONS'

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