About: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae

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About: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae
Creator	Wormser, Gary Horn, David Nunez, Miguel
Source	Elsevier; Medline; PMC
abstract	Abstract The skin and mucous membranes are the principal barriers to invasion of the body by microorganisms. Besides functioning as a mechanical barrier, the mucosae are endowed with an array of still poorly characterized specific and nonspecific host defense capabilities. These include the production of mucus, secretory immunoglobulin (IgA), lysozyme, lactoferrin, and alpha-antitrypsin, in conjunction with a low-grade exudation of leukocytes.1 In addition, the mucosal surfaces of the upper respiratory, gastrointestinal, and lower vaginal and urinary tracts support a large number of “nonpathogenic” microorganisms that comprise the so-called “normal flora.” This commensal flora plays an important and complex role in protecting the host from microbial invasion. Mechanisms for this protection likely include the following: (1) competition for the same nutrients (interference); (2) competition for the same receptors on host cells (tropism); (3) production of bacteriocins, that is, bacterial products that are toxic to other organisms, usually of the same species; and (4) stimulation of crossprotective immune factors such as the “natural antibodies.”1 The “normal” flora is inconstant and may be altered by dietary factors, debilitation, hormonal events (such as menstruation, pregnancy, and possibly use of oral contraceptives), personal hygiene, medications, intercurrent infection, and probably many others. Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these “nonpathogens.” This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). Invasion by “normal flora” may result in serious systemic illness. A clear example of the latter is the development of infective endocarditis caused by viridans streptococci following a dental procedure.
has issue date	1987-06-30(xsd:dateTime)
bibo:doi	10.1016/0738-081x(87)90013-7
bibo:pmid	3300930
has license	els-covid
sha1sum (hex)	da4f878f7c738dbe7bf8f0a77b95c34bd3a6de9d
schema:url	https://doi.org/10.1016/0738-081x%2887%2990013-7
resource representing a document's title	Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae
has PubMed Central identifier	PMC7172463
has PubMed identifier	3300930
schema:publication	Clinics in Dermatology
resource representing a document's body	covid:da4f878f7c738dbe7bf8f0a77b95c34bd3a6de9d#body_text
is schema:about of	named entity 'Vaginal' named entity 'Diseases' named entity 'bacteriologic' named entity 'acute infection' named entity 'pathogen' named entity 'oxidizing agents' named entity 'antibiotics' named entity 'gastrointestinal' named entity 'antibody response' named entity 'sore throat' named entity 'Clinics' named entity 'Wormser' named entity 'Clinics in Dermatology' named entity 'symptom complex' named entity 'infection' named entity 'jugular vein' named entity 'commensal relationship' named entity 'fever' named entity 'lactoferrin' named entity 'viral antigens' named entity 'metronidazole' named entity 'placebo' named entity 'penicillin' named entity 'Epstein-Barr' named entity 'throat culture' named entity 'penicillin-resistant' named entity 'penicillin' named entity 'benzathine penicillin' named entity 'antimicrobial' named entity 'streptococcal infections' named entity 'antibiotic' named entity 'streptococcal' named entity 'etiologically' named entity 'streptococcal' named entity 'Clinics in Dermatology' named entity 'antigens' named entity 'bacteriologic' named entity 'mucus' named entity 'streptococcal' named entity 'rheumatic fever' named entity 'mononucleosis' named entity 'respiratory tract infection' named entity 'pathogenesis' named entity 'penicillin' named entity 'rheumatic fever' named entity 'rheumatic fever' named entity 'Gingivitis' named entity 'erythema' named entity 'hoarseness' named entity 'bleeding gums' named entity 'Tennessee' named entity 'mucosal surfaces' named entity 'Endemic' named entity 'young adults' named entity 'splenomegaly' named entity 'throat culture' named entity 'penicillin' named entity 'anaerobic organisms' named entity 'lymphocytes' named entity 'infection' named entity 'asymptomatic' named entity 'penicillin' named entity 'sore throat' named entity 'Pharyngeal' named entity 'ampicillin' named entity 'streptococci' named entity 'antiviral drugs' named entity 'streptococcal' named entity 'Branhamella catarrhalis' named entity 'rheumatic fever' named entity 'rheumatic fever' named entity 'normal flora' named entity 'gingivitis' named entity 'peritonsillar abscess' named entity 'Group A streptococcus' named entity 'streptococcal pharyngitis' named entity 'streptococcal pharyngitis' named entity 'penicillin' named entity 'microorganisms'

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