About: Obesity & genetic predisposition with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Obesity & genetic predisposition with COVID-19
Creator	Zhu, Zhaozhong Hasegawa, Kohei Liang, Liming Camargo, Carlos Chan, Harvard Fujiogi, Michimasa Ma, Baoshan
Source	Elsevier; Medline; PMC
abstract	OBJECTIVE: We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data. Research Design and Methods. We analyzed data from 489,769 adults enrolled in the UK Biobank—a population-based cohort study. The exposures of interest are BMI categories and central obesity (e.g., larger waist circumference). Using genome-wide genotyping data, we also computed polygenic risk scores (PRSs) that represent an individual's overall genetic risk for each obesity trait. The outcome was severe COVID-19, defined by hospitalization for laboratory-confirmed COVID-19. RESULTS: Of 489,769 individuals, 33% were normal weight (BMI, 18.5–24.9 kg/m(2)), 43% overweight (25.0–29.9 kg/m(2)), and 24% obese (≥30.0 kg/m(2)). The UK Biobank identified 641 patients with severe COVID-19. Compared to adults with normal weight, those with a higher BMI had a dose-response increases in the risk of severe COVID-19, with the following adjusted ORs: for 25.0–29.9 kg/m(2), 1.40 (95%CI 1.14–1.73; P = 0.002); for 30.0–34.9 kg/m(2), 1.73 (95%CI 1.36–2.20; P < 0.001); for 35.0–39.9 kg/m(2), 2.82 (95%CI 2.08–3.83; P < 0.001); and for ≥40.0 kg/m(2), 3.30 (95%CI 2.17–5.03; P < 0.001). Likewise, central obesity was associated with significantly higher risk of severe COVID-19 (P < 0.001). Furthermore, larger PRS for BMI was associated with higher risk of outcome (adjusted OR per BMI PRS Z-score 1.14, 95%CI 1.05–1.24; P = 0.004). CONCLUSIONS: In this large population-based cohort, individuals with more-severe obesity, central obesity, or genetic predisposition for obesity are at higher risk of developing severe-COVID-19.
has issue date	2020-08-22(xsd:dateTime)
bibo:doi	10.1016/j.metabol.2020.154345
bibo:pmid	32835759
has license	no-cc
sha1sum (hex)	da7a4b4077e62e19035c36a3c7e6813b9ed6ac60
schema:url	https://doi.org/10.1016/j.metabol.2020.154345
resource representing a document's title	Obesity & genetic predisposition with COVID-19
has PubMed Central identifier	PMC7442576
has PubMed identifier	32835759
schema:publication	Metabolism
resource representing a document's body	covid:da7a4b4077e62e19035c36a3c7e6813b9ed6ac60#body_text
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