About: Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

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About: Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Creator	Bailey, Dalan Lambe, Teresa Wright, Daniel Hammond, John Burman, Alison Charleston, Bryan Gilbert, Sarah Dietrich, Isabelle Shelton, Holly Moffat, Katy Allen, Elizabeth Stevenson-Leggett, Phoebe Mioulet, Valerie Carroll, Miles Graham, Simon Mclean, Rebecca Owens, Raymond Spencer, Alexandra Tuthill, Tobias Edwards, Jane Asfor, Amin Belij-Rammerstorfer, Sandra Bhat, Sushant Bialy, Dagmara Browning, Clare Chiu, Chris Conceicao, Carina Crossley, Sylvia Gilbride, Ciaran Hayes, Jack Hollinghurst, Philippa Huo, Jiandong Ludi, Anna Martini, Veronica Newman, Joseph Pulido, David Sharpe, Hannah Tchilian, Elma Thakur, Nazia Ulaszewska, Marta Waters, Ryan Wilsden, Ginette
topic	covid:da8659c64ac86b10ca703bf15199a9dc721294f2#this
source	BioRxiv
abstract	Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.
has issue date	2020-06-20(xsd:dateTime)
bibo:doi	10.1101/2020.06.20.159715
has license	biorxiv
sha1sum (hex)	da8659c64ac86b10ca703bf15199a9dc721294f2
schema:url	https://doi.org/10.1101/2020.06.20.159715
resource representing a document's title	Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
schema:publication	bioRxiv
resource representing a document's body	covid:da8659c64ac86b10ca703bf15199a9dc721294f2#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/da8659c64ac86b10ca703bf15199a9dc721294f2
is schema:about of	named entity 'enhanced' named entity 'prime-boost' named entity 'SARS-CoV-2' named entity 'candidate' named entity 'immunisation' named entity 'COVID-19 vaccine' named entity 'immunogenicity' named entity 'Clinical development' named entity 'nCoV' named entity 'antigen' named entity 'April 2020' named entity 'nCoV' named entity 'ChAdOx1' named entity 'prime-boost' named entity 'vaccination' named entity 'primate' named entity 'vaccine' named entity 'LIVE/DEAD' named entity 'virus' named entity 'run concurrently' named entity 'vaccination' named entity 'CD44' named entity 'SARS-CoV-2' named entity 'correlation' named entity 'Thermo Fisher Scientific' named entity 'pig' named entity 'BioLegend' named entity 'IL-10' named entity 'SARS-CoV-2' named entity 'heterogeneity' named entity 'TMB' named entity 'adenoviral' named entity 'serum' named entity 'correlation' named entity 'immune response' named entity 'nCoV' named entity 'antibody titres' named entity 'IgG' named entity 'vaccination' named entity 'vector' named entity 'TNF-α'

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