About: Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2

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About: Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2
Creator	Aragona, Pasquale Freni, Francesco Galletti, Bruno Galletti, Cosimo Galletti, Francesco Gazia, Francesco Meduri, Alessandro Nicastro, Viviana
source	Elsevier; Medline; PMC
abstract	OBJECTIVE: The aim of this manuscript is to investigate transversally Ear Nose Throat (ENT) symptoms COVID-19 infection correlated and to study the neurotropism and neuroinvasiveness of the virus in the head-neck district through the investigation of the sense of smell, taste, tearing, salivation and hearing. METHODS: A total of 50 patients with laboratory-confirmed COVID-19 infection were included in our study. For each patient we evaluated the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS), the Summated Xerostomia Inventory-Dutch Version (SXI-DV), The Standardized Patient Evaluation of Eye Dryness (SPEED), Schirmer test I, the Hearing Handicap Inventory For Adults (HHIA) and the Tinnitus Handicap Inventory (THI). All the tests we carried out were performed during the active phase of the symptomatology from COVID-19 (Condition A) and 15 after SARS-COV-2 RT-PCR test negative (Condition B). RESULTS: A total of 46 patients (92%) had olfactory dysfunction related to the infection. The 70% of patients reported gustatory disorders. Cough, fever, headache and asthenia were the most prevalent symptoms. There was a statistically significant difference (p < 0,001) in sQOD-NS, SXI-DV, SPEED, Schirmer test, HHIA and THI between Condition A and Condition B. CONCLUSIONS: In our population there was an alteration of the sense of taste, of the sense of smell, dry eyes and of the oral cavity and an auditory discomfort, symptoms probably linked to the neurotropism of the virus. Furthermore, anosmia, dysgeusia and xerostomia are early symptoms of COVID-19, which can be exploited for an early quarantine and a limitation of viral contagion.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1016/j.amjoto.2020.102612
bibo:pmid	32574896
has license	no-cc
sha1sum (hex)	da877ccf3a876550c06316d1f177f52d95c31a2c
schema:url	https://doi.org/10.1016/j.amjoto.2020.102612
resource representing a document's title	Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2
has PubMed Central identifier	PMC7301823
has PubMed identifier	32574896
schema:publication	Am J Otolaryngol
resource representing a document's body	covid:da877ccf3a876550c06316d1f177f52d95c31a2c#body_text
is schema:about of	named entity 'action' named entity 'All' named entity 'authors' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'olfactory bulb' named entity 'trigeminal nerve's' named entity 'gustatory' named entity 'anxiety' named entity 'GERD' named entity 'triaging' named entity 'epithelium' named entity 'follow-up' named entity 'normal hearing' named entity 'Covid' named entity 'SARS-CoV-2' named entity 'tinnitus' named entity 'synapsing' named entity 'infection' named entity 'Middle East respiratory syndrome' named entity 'infection' named entity 'chemosis' named entity 'xerostomia' named entity 'coronaviruses' named entity 'parainfluenza' named entity 'anosmia' named entity 'physiological' named entity '8 days' named entity 'hyposmia' named entity 'COVID' named entity 'virus' named entity 'significant difference' named entity 'conjunctival' named entity 'tinnitus' named entity 'Schirmer test' named entity 'SARS-CoV' named entity 'glial cells' named entity 'SARS-CoV-2' named entity 'sense of smell' named entity 'olfactory mucosa' named entity 'Clinical data' named entity 'salivation' named entity 'infection' named entity 'province in China' named entity 'virus' named entity 'Europe' named entity 'asthma' named entity 'gustatory' named entity 'Toronto' named entity 'hearing loss' named entity 'ageusia' named entity 'COVID' named entity 'olfactory' named entity 'dry eyes' named entity 'March 2020' named entity 'CNS' named entity 'anosmia' named entity 'sputum production' named entity 'neuronal cells' named entity 'asymptomatic' named entity 'cellular receptor' named entity 'healthcare workers' named entity 'COVID' named entity 'Wuhan' named entity 'dysgeusia' named entity 'SARS-CoV' named entity 'COVID' named entity 'hyposmia' named entity 'New York' named entity 'COVID' named entity 'olfactory disorders' named entity 'COVID' named entity 'brain tissue' named entity 'COVID-19'

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