About: New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity

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About: New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
Creator	Zarubaev, Vladimir Anfimov, Pavel Kiselev, Oleg Salakhutdinov, Nariman Sokolova, Anastasiya Tretiak, Tatiana Yarovaya, Olga Beklemishev, Anatoly Lavrinenko, Valentina Pokrovsky, Andrey Pokrovsky, Michail Shernyukov, Andrey Vorozhtsov,
Source	Elsevier; Medline; PMC
abstract	Abstract The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length.
has issue date	2013-11-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2013.08.014
bibo:pmid	23993669
has license	els-covid
sha1sum (hex)	da955619aa259db9444269cebeeac040f17c8205
schema:url	https://doi.org/10.1016/j.bmc.2013.08.014
resource representing a document's title	New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity
has PubMed Central identifier	PMC7126328
has PubMed identifier	23993669
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:da955619aa259db9444269cebeeac040f17c8205#body_text
is schema:about of	named entity 'GENOTOXIC' named entity 'A(H1N1)' named entity 'reproduction' named entity 'cytotoxicity' named entity 'genotoxic' named entity 'camphor' named entity 'ANTIVIRAL ACTIVITY' named entity 'THEIR' named entity 'QUATERNARY AMMONIUM' named entity 'MODERATE ACTIVITY' named entity 'CELLS' named entity 'ATOMS' named entity 'DATA' named entity 'STUDIES' named entity 'NOVEL' named entity 'CYTOTOXICITY' named entity 'HIGHEST' named entity 'ALIPHATIC' named entity 'LENGTH' named entity 'CAMPHOR' named entity 'EFFECTS' named entity 'NEW' named entity 'ANTIVIRAL ACTIVITY' named entity 'EFFICIENCY' named entity 'REPRODUCTION' named entity 'INHIBITING' named entity 'CAMPHOR' named entity 'PARTICULAR' named entity 'REVEALED' named entity 'GENOTOXICITY' named entity 'BIOLOGICAL EVALUATION' named entity 'CEM' named entity 'THESE' named entity 'CELL LINES' named entity 'RESULTING' named entity 'TOXICITY' named entity 'CHAIN' named entity 'DESCRIBED' named entity 'CLOSE' named entity 'CYTOTOXICITY' named entity 'ACTIVITY' named entity 'RESULTS' named entity 'CYTO' named entity 'SEPARATED' named entity 'INFLUENZA VIRUS A' named entity 'SPACER' named entity 'OF INDEPENDENT' named entity 'MALIGNANT CELL' named entity 'COMPOUND' named entity 'SERIES' named entity 'NITROGEN' named entity 'AGENT' named entity 'SYNTHESIS' named entity 'AGREEMENT' named entity 'THEIR' covid:arg/da955619aa259db9444269cebeeac040f17c8205 named entity 'toxicity' named entity 'genotoxicity' named entity 'compounds' named entity 'dimeric' named entity 'activity' named entity 'quaternary' named entity 'data' named entity 'activity' named entity 'cyto' named entity 'toxicity' named entity 'genotoxic' named entity 'quaternary ammonium' named entity 'antiviral activity'

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