About: Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination

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About: Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination
Creator	Kraev, Igor Lange, Sigrun Criscitiello, Michael
source	Medline; PMC
abstract	The bovine immune system is known for its unusual traits relating to immunoglobulin and antiviral responses. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that cause post-translational deimination, contributing to protein moonlighting in health and disease. PADs also regulate extracellular vesicle (EV) release, forming a critical part of cellular communication. As PAD-mediated mechanisms in bovine immunology and physiology remain to be investigated, this study profiled deimination signatures in serum and serum-EVs in Bos taurus. Bos EVs were poly-dispersed in a 70–500 nm size range and showed differences in deiminated protein cargo, compared with whole sera. Key immune, metabolic and gene regulatory proteins were identified to be post-translationally deiminated with some overlapping hits in sera and EVs (e.g., immunoglobulins), while some were unique to either serum or serum-EVs (e.g., histones). Protein–protein interaction network analysis of deiminated proteins revealed KEGG pathways common for serum and serum-EVs, including complement and coagulation cascades, viral infection (enveloped viruses), viral myocarditis, bacterial and parasitic infections, autoimmune disease, immunodeficiency intestinal IgA production, B-cell receptor signalling, natural killer cell mediated cytotoxicity, platelet activation and hematopoiesis, alongside metabolic pathways including ferroptosis, vitamin digestion and absorption, cholesterol metabolism and mineral absorption. KEGG pathways specific to EVs related to HIF-1 signalling, oestrogen signalling and biosynthesis of amino acids. KEGG pathways specific for serum only, related to Epstein–Barr virus infection, transcription mis-regulation in cancer, bladder cancer, Rap1 signalling pathway, calcium signalling pathway and ECM-receptor interaction. This indicates differences in physiological and pathological pathways for deiminated proteins in serum-EVs, compared with serum. Our findings may shed light on pathways underlying a number of pathological and anti-pathogenic (viral, bacterial, parasitic) pathways, with putative translatable value to human pathologies, zoonotic diseases and development of therapies for infections, including anti-viral therapies.
has issue date	2020-04-19(xsd:dateTime)
bibo:doi	10.3390/ijms21082861
bibo:pmid	32325910
has license	cc-by
sha1sum (hex)	da97d77e4a1b41c06ad13dbee246961450d69fff
schema:url	https://doi.org/10.3390/ijms21082861
resource representing a document's title	Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination
has PubMed Central identifier	PMC7215346
has PubMed identifier	32325910
schema:publication	Int J Mol Sci
resource representing a document's body	covid:da97d77e4a1b41c06ad13dbee246961450d69fff#body_text
is schema:about of	named entity 'immunoglobulin' named entity 'phylogenetically conserved' named entity 'Deimination' named entity 'Metabolic' named entity 'BioRad' named entity 'iron homeostasis' named entity 'autoimmune diseases' named entity 'inflammatory diseases' named entity 'immune responses' named entity 'Sigma-Aldrich' named entity 'coagulation' named entity 'Ions' named entity 'IgA production' named entity 'complement proteins' named entity 'mucosal immunity' named entity 'immunoprecipitation' named entity 'HIV' named entity 'phagosome' named entity 'malaria' named entity 'teleost fish' named entity 'bovine' named entity 'epigenetic' named entity 'cow' named entity 'antimicrobial activity' named entity 'apolipoproteins' named entity 'p-value' named entity 'western blotting' named entity 'platelet activation' named entity 'protein' named entity 'LC-MS/MS' named entity 'phosphorylation' named entity 'lymphoid' named entity 'respiratory syncytial virus' named entity 'protein' named entity 'HIV' named entity 'BioRad' named entity 'Hemel Hempstead' named entity 'gene' named entity 'protein' named entity 'allograft' named entity 'cattle' named entity 'adipogenesis' named entity 'telomerase' named entity 'gene' named entity 'particle size' named entity 'cross-reacting' named entity 'cross-react' named entity 'Bos taurus' named entity 'amino acid' named entity 'deimination' named entity 'post-translational modification' named entity 'protein interactions' named entity 'co-expression' named entity 'dilated cardiomyopathy' named entity 'iron-binding' named entity 'cross-reacting' named entity 'cartilaginous fish' named entity 'deimination' named entity 'gene fusion' named entity 'hypoxia' named entity 'pathogenic bacteria' named entity 'selenium' named entity 'histone H3' named entity 'cytotoxicity' named entity 'viral myocarditis' named entity 'liquid chromatography' named entity 'secondary antibodies' named entity 'cross-react' named entity 'BioRad' named entity 'type II diabetes' named entity 'KEGG' named entity 'ontogeny' named entity 'metabolic pathways' named entity 'receptor' named entity 'bovine' named entity 'BioRad' named entity 'Rap1' named entity 'taxa' named entity 'SDS-PAGE'

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