About: T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

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About: T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
Creator	Srivastava, Shivani Campbell, Daniel Koch, Meghan Perdue, Nikole Smigiel, Kate Thomas, Kerri
source	Elsevier; Medline; PMC
abstract	Foxp3(+) regulatory T (Treg) cells limit inflammatory responses and maintain immune homeostasis. Although comprised of several phenotypically and functionally distinct subsets, the differentiation of specialized Treg cell populations within the periphery is poorly characterized. We demonstrate that the development of T-bet(+) Treg cells that potently inhibit T helper (Th)1 cell responses was dependent on the transcription factor STAT1, and occurred directly in response to interferon-γ produced by effector T cells. Additionally, delayed induction of the IL-12Rβ2 receptor component following STAT1 activation helped ensure that Treg cells do not readily complete STAT4-dependent Th1 cell development and lose their ability to suppress effector T cell proliferation. Thus, we define a pathway of abortive Th1 cell development that results in the specialization of peripheral Treg cells, and demonstrate that impaired expression of a single cytokine receptor helps maintain Treg cell suppressive function in the context of inflammatory Th1 cell responses.
has issue date	2012-09-01(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2012.05.031
bibo:pmid	22960221
has license	hybrid-oa
sha1sum (hex)	dafb3a55aa20a2e5a1ec2bcf3b7727c4345729e2
schema:url	https://doi.org/10.1016/j.immuni.2012.05.031
resource representing a document's title	T-bet(+) Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
has PubMed Central identifier	PMC3501343
has PubMed identifier	22960221
schema:publication	Immunity
resource representing a document's body	covid:dafb3a55aa20a2e5a1ec2bcf3b7727c4345729e2#body_text
is schema:about of	named entity 'cells' named entity 'T helper 1' named entity 'effector' named entity 'dependent' named entity 'helps' named entity 'ability' named entity 'peripheral' named entity 'define' named entity 'demonstrate' named entity 'Receptor' named entity 'cell' named entity 'Treg' named entity 'Th1 cell' named entity 'Treg' named entity 'homeostasis' named entity 'cytokine receptor' named entity 'Th1' named entity 'cell development' named entity 'interferon' named entity 'T-bet' named entity 'Receptor' named entity 'Th1' named entity 'Treg cells' named entity 'effector T cell' named entity 'IL-10' named entity 'effector T cells' named entity 'Tbx21' named entity 'gfp' named entity 'feed-forward' named entity 'STAT1' named entity 'lymphocytes' named entity 'activation site' named entity 'IL-12' named entity 'phosphorylation' named entity 'infection' named entity 'CD4 +' named entity 'Foxp3' named entity 'Foxp3' named entity 'IL-12' named entity 'CD3' named entity 'IFN-g' named entity 'mice' named entity 'Seattle' named entity 'Il12rb1' named entity 'Ifng' named entity 'STAT1' named entity 'spleens' named entity 'flow cytometric' named entity 'STAT4' named entity 'bone marrow' named entity 'effector T cells' named entity 'Treg cells' named entity 'UCSF' named entity 'mRNA expression' named entity 'Treg' named entity 'Treg' named entity 'infection' named entity 'cytokines' named entity 'Treg' named entity 'Th1' named entity 'Flow cytometric analysis' named entity 'Th1' named entity 'microbeads' named entity 'Treg cells' named entity 'Foxp3' named entity 'T-bet' named entity 'inflammation' named entity 'STAT4' named entity 'mice' named entity 'Flow cytometric analysis' named entity 'CD44' named entity 'OVA' named entity 'homeostasis' named entity 'inflammatory responses' named entity 'ng/mL' named entity 'chromosomal'

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