About: Cerebrospinal fluid chemokine patterns in children with enterovirus 71-related encephalitis

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About: Cerebrospinal fluid chemokine patterns in children with enterovirus 71-related encephalitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cerebrospinal fluid chemokine patterns in children with enterovirus 71-related encephalitis
Creator	Cai, Chunyan Chen, Zhimin Jiang, Yuan Li, Shuxian Liu, Jinling Xu, Yingchun Liu, China
Source	Medline; PMC
abstract	Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD) as well as neurological complications, such as encephalitis. The chemokines involved in the migration of leukocytes have increasingly been implicated in infectious diseases of the central nervous system. Few studies have evaluated the levels of chemokines in HMFD children with EV71-related encephalitis. In the present study, we evaluated the cerebrospinal fluid (CSF) levels of the chemokines IL-8, RANTES, MIG, MCP-1 and IP-10 in 99 children with EV71-related encephalitis and 22 children with febrile convulsion (FC). We found that the concentrations of IL-8, RANTES, MIG and IP-10 were significantly higher in HFMD children with encephalitis compared to patients with FC. Additionally, these four chemokines were dramatically reduced during convalescence. Inversely, the level of MCP-1 was lower in encephalitis patients than FC patients and was not significantly reduced during convalescence. Additionally, MIG was strongly correlated with IP-10 in encephalitis patients. Furthermore, the area under the ROC curve (AUC) of CSF MIG and IP-10 in distinguishing encephalitis from FC were 0.869 and 0.876, and the corresponding sensitivities/specificities were 67.7%/100.0% and 67.7%/95.5%, respectively. In conclusion, our results indicate that chemokines play important roles in the pathogenesis of EV71 infection.
has issue date	2018-01-26(xsd:dateTime)
bibo:doi	10.1038/s41598-018-19988-6
bibo:pmid	29374213
has license	cc-by
sha1sum (hex)	db12f0dcf2d4d913668f70ce1848c37ae2f31c69
schema:url	https://doi.org/10.1038/s41598-018-19988-6
resource representing a document's title	Cerebrospinal fluid chemokine patterns in children with enterovirus 71-related encephalitis
has PubMed Central identifier	PMC5786096
has PubMed identifier	29374213
schema:publication	Sci Rep
resource representing a document's body	covid:db12f0dcf2d4d913668f70ce1848c37ae2f31c69#body_text
is schema:about of	named entity 'level' named entity 'RANTES' named entity 'ENTEROVIRUS 71' covid:arg/db12f0dcf2d4d913668f70ce1848c37ae2f31c69 named entity 'FEBRILE CONVULSION' named entity 'STUDY' named entity 'LEVEL' named entity 'PRESENT' named entity 'PATIENTS' named entity 'RESULTS' named entity 'RANTES' named entity 'IP-10' named entity 'OUR' named entity 'ROLES' named entity '876' named entity 'EV71' named entity 'HIGHER' named entity 'ENCEPHALITIS' named entity 'EVALUATED' named entity 'IL-8' named entity 'INFECTION' named entity 'CONVALESCENCE' named entity 'THESE' named entity 'CONCENTRATIONS' named entity 'CORRELATED' named entity 'PLAY' named entity 'LOWER' named entity 'COMPARED' named entity 'CEREBROSPINAL FLUID' named entity 'CEREBROSPINAL FLUID' named entity 'MCP-1' named entity 'ENCEPHALITIS' named entity 'CHILDREN' named entity 'RELATED' named entity 'ROC CURVE' named entity 'LEVELS' named entity 'CSF' named entity 'CONCLUSION' named entity 'REDUCED' named entity 'AREA' named entity 'PATHOGENESIS' named entity 'CHEMOKINE' named entity 'CHEMOKINES' named entity 'RELATED' named entity 'IMPORTANT' named entity 'MIG' named entity 'PATTERNS' named entity 'HFMD' named entity 'CHILDREN' named entity 'DISTINGUISHING' named entity 'encephalitis' named entity 'infection' named entity 'HFMD' named entity 'RANTES' named entity 'higher' named entity 'compared' named entity 'MCP-1' named entity 'encephalitis' named entity 'patients' named entity 'Cerebrospinal fluid' named entity 'infection' named entity 'HFMD' named entity 'EV71' named entity 'MCP-1' named entity 'encephalitis' named entity 'EV71' named entity 'febrile convulsion' named entity 'IP-10' named entity 'Cerebrospinal fluid' named entity 'enterovirus 71' named entity 'Th1' named entity 'Th1' named entity 'negatively correlated' named entity 'infection' named entity 'ligands'

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