About: Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus)

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About: Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus)
Creator	Mätz-Rensing, Kerstin Bleyer, Martina Gruber-Dujardin, Eva Kunze, Marius
Source	PMC
abstract	Data on spontaneous pathology are substantially scarce for common marmosets, compared to other laboratory animals, but is essential for the interpretation of histological findings in the context of toxicological and experimental studies. Especially if common marmosets are used as experimental animals in respiratory research, detailed knowledge on the spectrum, occurrence, and incidence of spontaneous histopathological pulmonary lesions in this non-human primate species is required. In this study, lung tissue of 638 common marmosets from the marmoset colony of the German Primate Center was examined histologically. The analysis revealed a high incidence of predominantly mild and multifocal interstitial pneumonia (32.99 %) of unknown etiology in most cases. Only few marmosets exhibited lobar pneumonia (1.41 %) and bronchopneumonia (0.94), which were mainly caused by bacterial pathogens such as Bordetella bronchiseptica and Klebsiella pneumoniae. Lung immaturity and atelectasis were common histological findings in newborn marmosets. Typical background lesions included anthracosis (8.15 %), hemosiderosis (1.72 %), extramedullary hematopoiesis (11.6 %), mineralization (10.97 %), and inflammatory cell foci (10.34 %). In addition, three cases of pulmonary arteriopathy (0.47 %) and 1 case of foreign-body granuloma (0.16 %) were detected in the marmoset study cohort. The high prevalence of circulatory disturbances (congestion, edema, hemorrhage) and changes in air content (secondary atelectasis, alveolar emphysema) could partly be explained by euthanasia-related artifacts or agonal changes. The present study provides a comprehensive overview of the range and incidence of spontaneous pulmonary histopathology in common marmosets, serving as valuable reference data for the interpretation of lung lesions in toxicological and experimental marmoset studies.
has issue date	2017-03-01(xsd:dateTime)
bibo:doi	10.5194/pb-4-17-2017
bibo:pmid	32110688
has license	cc-by
sha1sum (hex)	db3f6cc774e724f7e9be22d7e76d489a1c131a46
schema:url	https://doi.org/10.5194/pb-4-17-2017
resource representing a document's title	Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus)
has PubMed Central identifier	PMC7041528
has PubMed identifier	32110688
schema:publication	Primate Biol
resource representing a document's body	covid:db3f6cc774e724f7e9be22d7e76d489a1c131a46#body_text
is schema:about of	named entity 'marmosets' named entity 'histological' named entity 'prevalence' named entity 'spontaneous' named entity 'spontaneous' named entity 'mineralization' named entity 'comprehensive' named entity 'toxicological' named entity 'hemorrhage' named entity 'histologically' named entity 'pathology' named entity 'common marmoset' named entity 'LUNG' named entity 'BUT' named entity 'REVEALED' named entity 'CONTENT' named entity 'BACTERIAL PATHOGENS' named entity 'CHANGES' named entity 'MINERALIZATION' named entity 'ADDITION' named entity 'RESEARCH' named entity 'RELATED' named entity 'CASES' named entity 'IMMATURITY' named entity 'RESPIRATORY' named entity 'STUDIES' named entity 'NON-HUMAN PRIMATE' named entity 'MILD' named entity 'REQUIRED' named entity 'MULTIFOCAL' named entity 'EXTRAMEDULLARY HEMATOPOIESIS' named entity 'ATELECTASIS' named entity 'CIRCULATORY' named entity 'PROVIDES' named entity 'LOBAR PNEUMONIA' named entity 'COMPREHENSIVE' named entity 'ANIMALS' named entity 'OCCURRENCE' named entity 'DATA' named entity 'CASE' named entity 'PATHOLOGY' named entity 'SPECTRUM' named entity 'PULMONARY' named entity 'PRIMATE' named entity 'INTERPRETATION' named entity 'HEMOSIDEROSIS' named entity 'EXPERIMENTAL' named entity 'RANGE' named entity 'COMMON' named entity 'BORDETELLA BRONCHISEPTICA' named entity 'HISTOLOGICALLY' named entity 'KNOWLEDGE' named entity 'HISTOLOGICAL' named entity 'EUTHANASIA' named entity 'FOCI' named entity 'LESIONS' named entity 'ALVEOLAR EMPHYSEMA' named entity 'HIGH PREVALENCE' named entity 'EXAMINED' named entity 'SPONTANEOUS' named entity 'COMPARED' named entity 'DETECTED' named entity 'TOXICOLOGICAL' named entity 'STUDY' named entity 'GERMAN' named entity 'BRONCHOPNEUMONIA' named entity 'SERVING' named entity 'UNKNOWN ETIOLOGY' named entity 'TYPICAL' named entity '638' named entity 'KLEBSIELLA PNEUMONIAE' named entity 'EXPLAINED' named entity 'BACKGROUND' named entity 'MARMOSET' named entity '288' named entity 'DETAILED' named entity 'CONTEXT' named entity 'AIR'

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