About: Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements
Creator	Guo, Hui-Chen Sun, Shi-Qi Gao, Yuan
source	Medline; PMC
abstract	Foot-and-mouth disease virus (FMDV) represses host translation machinery, blocks protein secretion, and cleaves cellular proteins associated with signal transduction and the innate immune response to infection. Non-structural proteins (NSPs) and non-coding elements (NCEs) of FMDV play a critical role in these biological processes. The FMDV virion consists of capsid and nucleic acid. The virus genome is a positive single stranded RNA and encodes a single long open reading frame (ORF) flanked by a long structured 5ʹ-untranslated region (5ʹ-UTR) and a short 3ʹ-UTR. The ORF is translated into a polypeptide chain and processed into four structural proteins (VP1, VP2, VP3, and VP4), 10 NSPs (L(pro), 2A, 2B, 2C, 3A, 3B(1–3), 3C(pro), and 3D(pol)), and some cleavage intermediates. In the past decade, an increasing number of studies have begun to focus on the molecular pathogenesis of FMDV NSPs and NCEs. This review collected recent research progress on the biological functions of these NSPs and NCEs on the replication and host cellular regulation of FMDV to understand the molecular mechanism of host–FMDV interactions and provide perspectives for antiviral strategy and development of novel vaccines.
has issue date	2016-06-22(xsd:dateTime)
bibo:doi	10.1186/s12985-016-0561-z
bibo:pmid	27334704
has license	cc-by
sha1sum (hex)	db5333b01a10f165ae516d30f9d1fbf96ab4b841
schema:url	https://doi.org/10.1186/s12985-016-0561-z
resource representing a document's title	Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements
has PubMed Central identifier	PMC4917953
has PubMed identifier	27334704
schema:publication	Virol J
resource representing a document's body	covid:db5333b01a10f165ae516d30f9d1fbf96ab4b841#body_text
is schema:about of	named entity 'pol' named entity 'acid' named entity 'capsid' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'ORF' named entity 'ROLE' named entity 'PROTEIN SECRETION' named entity 'NSPS' named entity 'BIOLOGICAL PROCESSES' named entity 'NON-STRUCTURAL PROTEINS' named entity 'UNDERSTAND' named entity 'FLANKED' named entity 'VACCINES' named entity 'CAPSID' named entity 'STUDIES' named entity 'INNATE IMMUNE RESPONSE' named entity 'UNTRANSLATED REGION' named entity 'CELLULAR REGULATION' named entity 'FOCUS' named entity 'ASSOCIATED WITH' named entity 'MOLECULAR MECHANISM' named entity 'RESEARCH' named entity 'VP4' named entity 'BIOLOGICAL FUNCTIONS' named entity 'FOOT-AND-MOUTH DISEASE VIRUS' named entity 'RECENT' named entity 'PLAY' named entity 'POLYPEPTIDE CHAIN' named entity 'PATHOGENESIS' named entity 'COLLECTED' named entity 'NOVEL' named entity 'STRUCTURED' named entity 'MACHINERY' named entity 'NUCLEIC ACID' named entity 'MOLECULAR' named entity 'DEVELOPMENT' named entity 'TRANSLATION' named entity 'CLEAVAGE' named entity 'ELEMENTS' named entity 'STRATEGY' named entity 'UTR' named entity 'DECADE' named entity 'OPEN READING FRAME' named entity 'INTERACTIONS' named entity 'VP2' named entity 'VIRION' named entity 'BLOCKS' named entity 'SINGLE' named entity 'VP3' named entity 'POSITIVE' named entity 'ANTIVIRAL' named entity 'INCREASING' named entity 'TRANSLATED' named entity 'PROVIDE' named entity 'LONG' named entity 'GENOME' named entity 'POL' named entity 'CELLULAR' named entity 'ELEMENTS' named entity 'NON-STRUCTURAL PROTEINS' named entity 'BIOLOGICAL FUNCTION' named entity 'NON-' named entity 'HAVE' named entity 'INFECTION' named entity 'CODING' named entity 'IN THE PAST' named entity 'RESPONSE TO' named entity 'STRUCTURAL PROTEINS' named entity 'PROTEINS' named entity 'SIGNAL TRANSDUCTION' named entity 'IS A' named entity 'CLEAVES' named entity 'PROCESSED' named entity 'RNA' named entity 'PRO' named entity 'NUMBER OF' named entity 'REPLICATION' named entity 'THESE' named entity 'NON-'

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