About: Lipoteichoic acid from Staphylococcus aureus exacerbates respiratory disease in porcine respiratory coronavirus-infected pigs

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About: Lipoteichoic acid from Staphylococcus aureus exacerbates respiratory disease in porcine respiratory coronavirus-infected pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lipoteichoic acid from Staphylococcus aureus exacerbates respiratory disease in porcine respiratory coronavirus-infected pigs
Creator	Van Gucht, Steven Atanasova, Kalina Barbé, Filip Duchateau, Luc Reeth, Kristien
Source	Elsevier; Medline; PMC
abstract	The objective of this study was to assess if lipoteichoic acid (LTA), produced by Staphylococcus aureus, exacerbates respiratory disease in porcine respiratory coronavirus (PRCV)-infected pigs, as has previously been shown with lipopolysaccharide. Piglets were inoculated with PRCV and 24 h later with S. aureus LTA. Clinical signs, lung virus titres, inflammatory cells and cytokines in bronchoalveolar lavage fluid (BALF) were compared with those of animals in PRCV- and LTA- inoculated control groups. All PRCV-LTA inoculated pigs except one developed severe respiratory disease, whereas clinical signs in the control groups were minimal or absent. Virus titres and grossly visible pulmonary lesions were similar in the PRCV-LTA- and PRCV-inoculated groups and were not detected in the LTA-group. Neutrophil percentages in BALF were higher in the PRCV-LTA than in the PRCV group. There was no significant difference in interferon (IFN)-γ, interleukin (IL)-1, IL-6, IL-12/IL-23 and tumour necrosis factor (TNF)-α concentrations in BALF between the PRCV-LTA and PRCV groups, but levels of IL-6, IL-12/IL-23 and IFN-γ were higher in the PRCV-LTA-inoculated than in the LTA-inoculated controls. The findings suggest that the experimentally-induced respiratory disease was not mediated by cytokine over-production, but rather reflected the concerted action of particular cytokine interactions and/or as yet unidentified mediators. This is the first in vivo study to report the synergistic interaction between a virus and LTA in enhancing the severity of respiratory disease in the pig. Given that Gram-positive bacteria, capable of producing LTA, are commonly found in pig accommodation, the role of this compound in the development of the porcine respiratory disease complex requires further investigation.
has issue date	2011-05-01(xsd:dateTime)
bibo:doi	10.1016/j.tvjl.2010.03.001
bibo:pmid	20409735
has license	bronze-oa
sha1sum (hex)	db6e3b9c66d528a48f4816ebceb16e6c263f45b9
schema:url	https://doi.org/10.1016/j.tvjl.2010.03.001
resource representing a document's title	Lipoteichoic acid from Staphylococcus aureus exacerbates respiratory disease in porcine respiratory coronavirus-infected pigs
has PubMed Central identifier	PMC2932768
has PubMed identifier	20409735
schema:publication	The Veterinary Journal
resource representing a document's body	covid:db6e3b9c66d528a48f4816ebceb16e6c263f45b9#body_text
is schema:about of	named entity 'STAPHYLOCOCCUS AUREUS' named entity 'Staphylococcus aureus' named entity 'bronchoalveolar lavage fluid' named entity 'RESPIRATORY DISEASE' named entity 'S. AUREUS' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'OBJECTIVE' named entity 'INFLAMMATORY CELLS' named entity 'COMPARED' named entity 'PREVIOUSLY' named entity 'LUNG' named entity 'EXACERBATES' covid:arg/db6e3b9c66d528a48f4816ebceb16e6c263f45b9 named entity 'EXACERBATES' named entity 'STAPHYLOCOCCUS AUREUS' named entity 'ASSESS' named entity 'LTA' named entity 'ANIMALS' named entity 'PORCINE RESPIRATORY CORONAVIRUS' named entity 'INFECTED' named entity 'PIGS' named entity 'LIPOTEICHOIC ACID' named entity 'CYTOKINES' named entity 'CONTROL GROUPS' named entity 'STUDY' named entity 'RESPIRATORY DISEASE' named entity 'LIPOTEICHOIC ACID' named entity 'LATER' named entity 'PORCINE RESPIRATORY CORONAVIRUS' named entity 'CLINICAL SIGNS' named entity 'INFECTED' named entity 'PIGS' named entity 'VIRUS' named entity 'LIPOPOLYSACCHARIDE' named entity 'cytokines' named entity 'porcine' named entity 'LTA' named entity 'LTA' named entity 'respiratory disease' named entity 'porcine' named entity 'titres' named entity 'BALF' named entity 'inoculation' named entity 'sub-unit' named entity 'LTA' named entity 'Histamine' named entity 'treatment groups' named entity 'mast cells' named entity 'S. aureus' named entity 'cytokine' named entity 'IL-8' named entity 'depression' named entity 'co-receptor' named entity 'LTA' named entity 'coagulase' named entity 'TNF-a' named entity 'sub-clinical' named entity 'left lung' named entity 'inoculation' named entity 'cytokine' named entity 'LTA' named entity 'dyspnoea' named entity 'maximal levels' named entity 'milk' named entity 'clinical signs' named entity 'TNF-a' named entity 'TNF-a' named entity 'IL-12' named entity 'Animal Welfare' named entity 'IL-12' named entity 'positive-pressure ventilation' named entity 'mice' named entity 'cytokines' named entity 'Van Reeth' named entity 'LTA' named entity 'cell count' named entity 'IFN'

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