About: Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

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About: Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
Creator	Tsiodras, Sotirios Andreakos, Evangelos Koltsida, Ourania Koutsoukou, Antonia Mentis, Andreas Koulouris, Nikolaos Fragkou, Paraskevi Koukaki, Evangelia Rovina, Nikoletta Galani, Lampropoulou, Vicky Manioudaki, Panou, Vasiliki Pavlos, Eleftherios Triantafyllia, Vasiliki
source	MedRxiv
abstract	A central paradigm of immunity is that interferon (IFN) mediated antiviral responses precede the pro-inflammatory ones, optimizing host protection and minimizing collateral damage. Here, we report that for COVID-19 this does not apply. By investigating temporal IFN and inflammatory cytokine patterns in 32 COVID-19 patients hospitalized for pneumonia and longitudinally followed for the development of respiratory failure and death, we reveal that IFN-{lambda} and type I IFN production is both diminished and delayed, induced only in a fraction of patients as they become critically ill. On the contrary, pro-inflammatory cytokines such as TNF, IL-6 and IL-8 are produced before IFNs, in all patients, and persist for a prolonged time. By comparison, in 16 flu patients hospitalized for pneumonia with similar clinicopathological characteristics to COVID-19 and 24 milder non-hospitalized flu patients IFN-{lambda} and type I IFN are robustly induced, earlier, at higher levels and independently of disease severity, while pro-inflammatory cytokines are only acutely and transiently produced. Notably, higher IFN-{lambda} levels in COVID-19 patients correlate with lower viral load in bronchial aspirates and faster viral clearance, and a higher IFN-{lambda}:type I IFN ratio with improved outcome of critically ill patients. Moreover, altered cytokine patterns in COVID-19 patients correlate with longer hospitalization time and higher incidence of critical disease and mortality compared to flu. These data point to an untuned antiviral response in COVID-19 contributing to persistent viral presence, hyperinflammation and respiratory failure.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1101/2020.08.21.20179291
has license	medrxiv
sha1sum (hex)	db8d53f904ae46f86879b7f91f43e63b439ec78c
schema:url	https://doi.org/10.1101/2020.08.21.20179291
resource representing a document's title	Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
resource representing a document's body	covid:db8d53f904ae46f86879b7f91f43e63b439ec78c#body_text
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