About: Prevalence of Respiratory Viral Infections in Korean Adult Asthmatics With Acute Exacerbations: Comparison With Those With Stable State

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prevalence of Respiratory Viral Infections in Korean Adult Asthmatics With Acute Exacerbations: Comparison With Those With Stable State
Creator	Bae, Da-Jeong Kim, Ji-Na Park, Choon-Sik Park, Jong-Sook Seo, Ki-Hyun Baek, Dong-Gyu Chang, Hun-Soo Kim, Myung-Shin Kim, Yong-Hoon Lee, Ho-Sung Lee, Jun-Suk Son, Ji-Hye
Source	Medline; PMC
abstract	PURPOSE: Viral infections are involved in ~50% of exacerbations among Caucasian adult asthmatics. However, there have been few reports on the causative virus of exacerbations in Korean adult asthmatics. Thus, we compared frequencies and types of viruses between lower respiratory tract illnesses (LRTIs) with exacerbations (exacerbated LRTIs) and those without exacerbations (stable LRTIs) to evaluate contribution of respiratory viruses to exacerbations. METHODS: Viral RNA was extracted from sputum using the Viral Gene-spin™ Kit. Reverse transcription-polymerase chain reaction (RT-PCR) was performed to detect adenovirus (ADV), metapneumovirus (MPV), parainfluenza virus (PIV) 1/2/3, influenza virus (IFV) A, IFV B, respiratory syncytial virus (RSV) A/B, and rhinovirus (RV) A. RESULTS: Among the 259 patients, 210 underwent a single sputum examination, and the remaining 49 underwent 2 to 4 sputum examinations. Virus was detected in 68 of the 259 exacerbated episodes and in 11 of the 64 stable episodes. Among the exacerbated episodes, RV was the most frequently detected virus, followed by influenza A, parainfluenza, RSV A/B, and ADV. Among the 11 stable episodes, RV was most frequently detected. Detection rates of these viruses did not differ between the 2 groups (P>0.05). Thirty-five patients underwent the virus examination at 2 episodes of exacerbation, while 14 patients underwent at each time of exacerbated and stable episodes. Virus detection rate at the second examination was significantly higher in cases with 2 exacerbation episodes than in those with initial exacerbation and sequential stable episodes (P=0.003). A seasonal pattern was noted in the detection rates of RV (September to December), IFV (January to April), PIV (May to September), and RSV A/B (September to April). CONCLUSIONS: Respiratory viruses were identified in approximately 20% of LRTI irrespective of the presence of asthma exacerbation. RV and IFV A/B were most frequently detected. A group of patients experienced frequent viral infections followed by asthma exacerbations.
has issue date	2017-08-04(xsd:dateTime)
bibo:doi	10.4168/aair.2017.9.6.491
bibo:pmid	28913988
has license	cc-by-nc
sha1sum (hex)	db94e7aa6b683896a9ff5a239003a0c351f60041
schema:url	https://doi.org/10.4168/aair.2017.9.6.491
resource representing a document's title	Prevalence of Respiratory Viral Infections in Korean Adult Asthmatics With Acute Exacerbations: Comparison With Those With Stable State
has PubMed Central identifier	PMC5603477
has PubMed identifier	28913988
schema:publication	Allergy Asthma Immunol Res
resource representing a document's body	covid:db94e7aa6b683896a9ff5a239003a0c351f60041#body_text
is schema:about of	named entity 'COMPARISON' named entity 'Prevalence' named entity 'With' named entity 'RESPIRATORY' named entity 'STABLE' named entity 'ADULT' named entity 'VIRAL INFECTIONS' named entity 'ACUTE EXACERBATIONS' named entity 'PREVALENCE' named entity 'STATE' named entity 'KOREAN' named entity 'ASTHMATICS' named entity 'FVC' named entity 'Korea' named entity 'acute exacerbation' named entity 'virus' named entity 'Infections' named entity 'Prevalence' named entity 'Asthmatics' named entity 'FEV1' named entity 'virus' named entity 'asthmatic' named entity 'IFV' named entity 'influenza virus' named entity 'sputum' named entity 'asthma' named entity 'wheezing' named entity 'asthma' named entity 'viral infection' named entity 'LRTI' named entity 'viruses' named entity 'electrophoresis' named entity 'LRTI' named entity 'virus' named entity 'virus infections' named entity 'acute asthma' named entity 'sputum' named entity 'cohort study' named entity 'Sputum' named entity 'longitudinal study' named entity 'asthmatics' named entity 'allergens' named entity 'FEV1' named entity 'inhalation' named entity 'viruses' named entity 'post-nasal drip' named entity 'RT-PCR' named entity 'sputum' named entity 'IgE' named entity 'RSV' named entity 'sputum' named entity 'RSV' named entity 'hemocytometer' named entity 'asthma' named entity 'Global Initiative for Asthma' named entity 'lung cancer' named entity 'viral infections' named entity 'asthmatics' named entity 'viruses' named entity 'viruses' named entity 'Supernatants' named entity 'virus' named entity 'nasal congestion' named entity 'Korea' named entity 'sputum' named entity 'asthma' named entity 'IFV' named entity 'upper respiratory tract' named entity 'sensitizing' named entity 'asthma'

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