About: Inhibitors of virus replication: recent developments and prospects

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibitors of virus replication: recent developments and prospects
Creator	Leevi, Julia Tero Ahola, Kääriäinen
Source	Medline; PMC
abstract	The search for inhibitors of viral replication is dependent on understanding the events taking place at the molecular level during viral infection. All the essential steps during the viral life cycle are potential targets for antiviral drugs. Classical inhibitors of herpesvirus replication cause chain termination during viral DNA replication. Similarly, the HIV reverse transcriptase is the major target of anti-HIV compounds. The broad-spectrum antiviral agent ribavirin affects viral nucleic acid replication by multiple mechanisms. Another major enzyme encoded by many viruses is a protease responsible for the processing of virus-encoded polyproteins. The HIV protease has been very successfully targeted, and hepatitis C virus and rhinovirus protease inhibitors are being actively developed. The complex series of interactions during virus entry is a rapidly emerging and promising target for inhibitors of HIV and many other viruses. New anti-influenza drugs inhibit virus release from infected cells. Several stages of the viral life cycle remain incompletely characterized and are therefore poorly exploited in antiviral strategies. These include, among others, the RNA capping reactions catalyzed by many viruses, as well as the membrane association of replication complexes which is common to all positive-strand RNA viruses.
has issue date	2004-12-09(xsd:dateTime)
bibo:doi	10.1007/s00253-004-1783-3
bibo:pmid	15592828
has license	no-cc
sha1sum (hex)	dba333288b0b21947b70f8726c0358b59819d367
schema:url	https://doi.org/10.1007/s00253-004-1783-3
resource representing a document's title	Inhibitors of virus replication: recent developments and prospects
has PubMed Central identifier	PMC7082807
has PubMed identifier	15592828
schema:publication	Appl Microbiol Biotechnol
resource representing a document's body	covid:dba333288b0b21947b70f8726c0358b59819d367#body_text
is schema:about of	named entity 'VIRUS REPLICATION' named entity 'DEPENDENT' named entity 'MOLECULAR' named entity 'CHAIN TERMINATION' named entity 'PLACE' named entity 'STEPS' named entity 'INHIBITORS' named entity 'DEVELOPMENTS' named entity 'REVIEW' named entity 'LEVEL' named entity 'ANTIVIRAL DRUGS' named entity 'CAUSE' named entity 'VIRAL DNA REPLICATION' named entity 'INHIBITORS' named entity 'POTENTIAL' named entity 'REPLICATION' named entity 'MINI' named entity 'VIRAL REPLICATION' named entity 'ESSENTIAL' named entity 'HERPESVIRUS' named entity 'SEARCH' named entity 'RECENT' named entity 'TARGETS' named entity 'TAKING' named entity 'VIRAL INFECTION' named entity 'EVENTS' named entity 'UNDERSTANDING' named entity 'CLASSICAL' named entity 'The' named entity 'prospects' named entity 'antiviral drugs' named entity 'molecular level' named entity 'hepatitis' named entity 'enfuvirtide' named entity 'human trials' named entity 'flavivirus' named entity 'viral infections' named entity 'protein' named entity 'replicase' named entity 'life cycle' named entity 'meningoencephalitis' named entity 'NNRTIs' named entity 'Hepatitis C virus' named entity 'RNA viruses' named entity 'ribavirin' named entity 'negative strand RNA viruses' named entity 'NS5B' named entity 'capsid' named entity 'endosomes' named entity 'methyltransferase' named entity 'infection' named entity 'clinical studies' named entity 'reverse transcriptase' named entity 'Viramidine' named entity 'protein' named entity 'ribavirin' named entity 'infection' named entity 'molecule' named entity 'poliovirus' named entity 'VX-950' named entity 'dengue' named entity 'mRNAs' named entity 'SARS-CoV' named entity 'viral RNA' named entity 'peptidomimetic' named entity 'enzyme' named entity 'HCV' named entity 'NS3' named entity 'Protease inhibitors' named entity 'protein synthesis' named entity 'pathogenic viruses' named entity 'Phase II clinical trials' named entity 'membrane association' named entity 'mosquito' named entity 'receptor' named entity 'serine protease inhibitor' named entity 'hepatoma' named entity 'nucleoside' named entity 'hydrophobic residues' named entity 'interferon'

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