About: Protective role of follicular CXCR5(+)CD8(+) T cells against dengue virus 2 infection

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About: Protective role of follicular CXCR5(+)CD8(+) T cells against dengue virus 2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective role of follicular CXCR5(+)CD8(+) T cells against dengue virus 2 infection
Creator	Wang, Hong Chen, Sufeng Qiu, Liannv Yu, Qinhua Zhao, Zhao Liu, Jiejing
Source	Elsevier; Medline; PMC
abstract	Follicular CXCR5(+)CD8(+) T cells have antiviral effects in chronic virus infection, but the roles of these cells during dengue virus 2 (DENV2) infection remain poorly understood. OBJECTIVE: This study was conducted to analyzed in detail the dynamic changes and functional properties of circulating follicular CXCR5(+)CD8(+) T cells to explore their effects on DENV2 infection. METHODS: Circulating follicular CXCR5(+)CD8(+) T cells and cytokines were analyzed by flow cytometry in DENV2 patients at difference days after DENV2 infection. CD8(+) T cells were isolated and purified from DENV2 patients, then were stimulated with NS1 peptides and TCR stimulant. After cultivation, multiple parameters were tested. RESULTS: (1) CXCR5(+)CD8(+) T cells emerged after DENV2 infection, with high PD-1 expression, and were correlated with the reduction in DENV2 RNA viral loads. (2) PD-1(+)CXCR5(+)CD8(+) T cells were negatively associated with disease progression. (3) Serum IFN-γ, IL-6 and IL-10 levels were increased late in the course of DENV2 infection. (4) CXCR5(+)CD8(+) T cells from DENV2 patients exhibited increased cytotoxicity and IFN-γ and IL-10 secretion. CONCLUSION: CXCR5(+)CD8(+) T cells could play a protective role in dengue pathogenesis and may be a novel strategy for controlling DENV2 infection and vaccine development.
has issue date	2019-03-20(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2019.03.024
bibo:pmid	30904675
has license	no-cc
sha1sum (hex)	dbba5c142b345bf7c4fc7cc75762e6de2513272d
schema:url	https://doi.org/10.1016/j.ijid.2019.03.024
resource representing a document's title	Protective role of follicular CXCR5(+)CD8(+) T cells against dengue virus 2 infection
has PubMed Central identifier	PMC7110549
has PubMed identifier	30904675
schema:publication	Int J Infect Dis
resource representing a document's body	covid:dbba5c142b345bf7c4fc7cc75762e6de2513272d#body_text
is schema:about of	named entity 'THEIR' named entity 'THESE' named entity 'PATIENTS' named entity '283' named entity '282' named entity 'INFECTION' named entity 'IFN-G' named entity 'CHRONIC' named entity 'LEVELS' named entity 'IL-10' named entity 'CYTOTOXICITY' named entity 'BUT' named entity 'INCREASED' named entity 'COURSE' named entity 'PARAMETERS' named entity 'IL-6' named entity 'DENGUE VIRUS 2' named entity 'CXCR5' named entity 'CORRELATED' named entity 'DENGUE' named entity 'MULTIPLE' named entity 'CD8' named entity 'study' named entity 'CD8' named entity 'cytokines' named entity 'After' named entity 'cytotoxicity' named entity 'RESULTS' named entity 'HAVE' named entity 'UNDERSTOOD' named entity 'DIFFERENCE' named entity 'CD8' named entity 'PROTECTIVE ROLE' named entity 'FLOW CYTOMETRY' named entity 'CONTROLLING' named entity 'SERUM' named entity 'OBJECTIVE' named entity 'TCR' named entity 'PD-1' named entity 'RNA' named entity 'HIGH' named entity 'PROPERTIES' named entity 'CD8' named entity 'METHODS' named entity 'PLAY' named entity 'EFFECTS' named entity 'VIRUS INFECTION' named entity 'STIMULANT' named entity 'FOLLICULAR' named entity 'CXCR5' named entity 'POORLY' named entity 'STUDY' named entity 'PATHOGENESIS' named entity 'CHANGES' named entity 'LATE' named entity 'CULTIVATION' named entity 'REDUCTION' named entity 'PROTECTIVE ROLE' named entity 'NS1' named entity 'DISEASE PROGRESSION' named entity 'VACCINE DEVELOPMENT' named entity 'CELLS' named entity 'PEPTIDES' named entity 'ANTIVIRAL' named entity 'STIMULATED' named entity 'ANALYZED' named entity 'PURIFIED' named entity 'MAY BE A' named entity 'DENGUE VIRUS 2' named entity 'INFECTION' named entity 'T CELLS' named entity 'NOVEL' named entity 'ISOLATED' named entity 'EXPRESSION' named entity 'FOLLICULAR' named entity 'CYTOKINES'

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