About: CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation

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About: CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation
Creator	Kim, Koanhoi Park, Sang-Youel Uyangaa, Erdenebelig Kim, Jin Patil, Ajit Bum, Seong Choi, Jin Lee, John Woo, Young Eo, Kug Seong, &
Source	PMC
abstract	Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privileged CNS upon infection with neurotropic viruses has not been completely defined. Notably, DC roles in regulating innate CD11b(+)Ly-6C(hi) monocyte functions during neuroinflammation have not yet been addressed. Using selective ablation of CD11c(hi)PDCA-1(int/lo) DCs without alteration in CD11c(int)PDCA-1(hi) plasmacytoid DC number, we found that CD11c(hi) DCs are essential to control neuroinflammation caused by infection with neurotropic Japanese encephalitis virus, through early and increased infiltration of CD11b(+)Ly-6C(hi) monocytes and higher expression of CC chemokines. More interestingly, selective CD11c(hi) DC ablation provided altered differentiation and function of infiltrated CD11b(+)Ly-6C(hi) monocytes in the CNS through Flt3-L and GM-CSF, which was closely associated with severely enhanced neuroinflammation. Furthermore, CD11b(+)Ly-6C(hi) monocytes generated in CD11c(hi) DC-ablated environment had a deleterious rather than protective role during neuroinflammation, and were more quickly recruited into inflamed CNS, depending on CCR2, thereby exacerbating neuroinflammation via enhanced supply of virus from the periphery. Therefore, our data demonstrate that CD11c(hi) DCs provide a critical and unexpected role to preserve the immune-privileged CNS in lethal neuroinflammation via regulating the differentiation, function, and trafficking of CD11b(+)Ly-6C(hi) monocytes.
has issue date	2015-12-02(xsd:dateTime)
bibo:doi	10.1038/srep17548
bibo:pmid	26626303
has license	cc-by
sha1sum (hex)	dc3d3e12aa6087b1141910cf58ac7f37c8cd0793
schema:url	https://doi.org/10.1038/srep17548
resource representing a document's title	CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation
has PubMed Central identifier	PMC4667186
has PubMed identifier	26626303
schema:publication	Sci Rep
resource representing a document's body	covid:dc3d3e12aa6087b1141910cf58ac7f37c8cd0793#body_text
is schema:about of	named entity 'NEUROINFLAMMATION' named entity 'selective' named entity 'Therefore' named entity 'ablation' named entity 'CD11c' named entity 'selective' named entity 'CD11c' named entity 'NEUROINFLAMMATION' named entity 'CNS' named entity 'PRESERVE' named entity 'PRIVILEGED' named entity 'LETHAL' named entity 'INFECTION' named entity 'INFLAMED' named entity 'PLASMACYTOID DC' named entity 'VIRUS' named entity 'ENVIRONMENT' named entity 'IMMUNE' named entity 'RATHER' named entity 'OUR' named entity 'SUPPLY' named entity 'ROLE' named entity 'PERIPHERY' named entity 'SELECTIVE' named entity 'MONOCYTES' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'HAVE' named entity 'GENERATED' named entity 'CRITICAL' named entity 'ENHANCED' named entity 'TO CONTROL' named entity 'EXPRESSION' named entity 'USING' named entity 'ALTERED' named entity 'SEVERELY' named entity 'DCS' named entity 'DATA' named entity 'ESSENTIAL' named entity 'LY-6C' named entity 'HIGHER' named entity 'CD11C' named entity 'REGULATE' named entity 'LETHAL' named entity 'LY-6C' named entity 'PDCA-1' named entity 'CC CHEMOKINES' named entity 'MONOCYTE' named entity 'REGULATING' named entity 'MONOCYTE DIFFERENTIATION' named entity 'ABLATION' named entity 'PRESERVE' named entity 'OPEN' named entity 'CD11C' named entity 'IMMUNE' named entity 'PROVIDE' named entity 'PRIVILEGED' named entity 'DENDRITIC CELLS' named entity 'CCR2' named entity 'ALTERATION' named entity 'DIFFERENTIATION' named entity 'INFILTRATION' named entity 'EARLY' named entity 'FLT3-L' named entity 'UNEXPECTED' named entity 'PROTECTIVE ROLE' named entity 'CD11B' named entity 'PROVIDED' named entity 'GM-CSF' named entity 'ASSOCIATED WITH' named entity 'FUNCTIONS' named entity 'CNS'

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