About: A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus

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About: A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus
Creator	Al-Nazawi, Mohammed Kandeel, Mahmoud Al-Taher, Abdulla Kwon, Hyung-Joo Byoung, \| Park, Kwon
topic	covid:dc4e4ee20954b6635e768b4b35d2c4e4e7a89839#this
Source	Medline; PMC
abstract	The Middle East respiratory syndrome coronavirus (MERS‐CoV) is an emerging virus that causes infection with a potentially fatal outcome. Dendrimers are highly branched molecules that can be added to antiviral preparations to improve their delivery, as well as their intrinsic antiviral activity. Studies on identifying anti‐MERS‐CoV agents are few. Three types of polyanionic dendrimers comprising the terminal groups sodium carboxylate (generations 1.5, 2.5, 3.5, and 4.5), hydroxyl (generations 2, 3, 4, and 5), and succinamic acid (generations 2, 3, 4, and 5) and polycationic dendrimers containing primary amine (generations 2, 3, 4, and 5) were used to assess their antiviral activity with the MERS‐CoV plaque inhibition assay. The hydroxyl polyanionic set showed a 17.36% to 29.75% decrease in MERS‐CoV plaque formation. The most potent inhibition of MERS‐CoV plaque formation was seen by G(1.5)‐16COONa (40.5% inhibition), followed by G(5)‐128SA (39.77% inhibition). In contrast, the cationic dendrimers were cytotoxic to Vero cells. Polyanionic dendrimers can be added to antiviral preparations to improve the delivery of antivirals, as well as the intrinsic antiviral activity.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1002/jmv.25928
bibo:pmid	32330296
has license	no-cc
sha1sum (hex)	dc4e4ee20954b6635e768b4b35d2c4e4e7a89839
schema:url	https://doi.org/10.1002/jmv.25928
resource representing a document's title	A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus
has PubMed Central identifier	PMC7264540
has PubMed identifier	32330296
schema:publication	J Med Virol
resource representing a document's body	covid:dc4e4ee20954b6635e768b4b35d2c4e4e7a89839#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/dc4e4ee20954b6635e768b4b35d2c4e4e7a89839
is schema:about of	named entity 'preparations' named entity 'groups' named entity 'Middle East respiratory syndrome' named entity 'activity' named entity 'terminal' named entity 'molecules' named entity 'anionic' named entity 'SET' named entity 'CAUSES' named entity 'ASSESS' named entity 'USED' named entity 'ADDED' named entity 'DENDRIMERS' named entity 'coronavirus' named entity 'carboxylate' named entity 'acid' named entity 'virus classification' named entity 'Vero' named entity 'agents' named entity 'dendrimers' named entity 'primary amine' named entity 'cells' named entity 'generations' named entity 'antiviral' named entity 'set' named entity 'sodium' named entity 'dendrimers' named entity 'carboxylate' named entity 'polycationic' named entity 'coronavirus' named entity 'plaque formation' named entity 'virus classification' named entity 'plaque formation' named entity 'primary amine' named entity '3.5' named entity 'antiviral' named entity 'MERS-CoV' named entity 'Dendrimers' named entity 'antiviral' named entity 'antivirals' named entity 'MERS-CoV' named entity 'anionic and cationic' named entity 'dendrimers' named entity 'transferred to humans' named entity 'cytochrome' named entity 'SARS' named entity 'Dendrimers' named entity 'monomers' named entity 'Middle East respiratory syndrome coronavirus' named entity 'hemoglobin' named entity 'biomimetics' named entity 'beta-sheets' named entity 'Dendrimers' named entity 'King Faisal University' named entity 'Arabian peninsula' named entity 'communicable disease' named entity 'assay' named entity 'protease' named entity 'repetitive sequences' named entity 'dendrimer' named entity 'MERS-CoV' named entity '4 nm' named entity 'MERS-CoV' named entity 'dendrimers' named entity 'MERS-CoV' named entity 'globular proteins' named entity '10 nm' named entity 'Dendrimers' named entity 'dendrimer' named entity 'moiety' named entity 'pilot study' named entity 'cationic' named entity 'cell cultures' named entity 'antiviral activity'

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