About: AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
Creator	Evans, A Grahame, D
Source	Medline; PMC
abstract	We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here, we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to the central regulation of feeding and food choice. We propose, therefore, that oxygen supply to the body is aligned with not only the quantity we eat, but also nutrient-based diet selection, and that the cell-specific expression pattern of AMPK subunit isoforms is critical to appropriate system alignment in this respect. Currently available information on how oxygen supply may be aligned with feeding and food choice, or vice versa, through our motivation to breathe and select particular nutrients is sparse, fragmented and lacks any integrated understanding. By addressing this, we aim to provide the foundations for a clinical perspective that reveals untapped potential, by highlighting how aberrant cell-specific changes in the expression of AMPK subunit isoforms could give rise, in part, to known associations between metabolic disease, such as obesity and type 2 diabetes, sleep-disordered breathing, pulmonary hypertension and acute respiratory distress syndrome.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.3390/ijms21103518
bibo:pmid	32429235
has license	cc-by
sha1sum (hex)	dc8966c49f9e7f0506b4eebb1787151aa30ed61c
schema:url	https://doi.org/10.3390/ijms21103518
resource representing a document's title	AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
has PubMed Central identifier	PMC7279029
has PubMed identifier	32429235
schema:publication	Int J Mol Sci
resource representing a document's body	covid:dc8966c49f9e7f0506b4eebb1787151aa30ed61c#body_text
is schema:about of	named entity 'subunit' named entity 'breathe' named entity 'oxygen' named entity 'highlighting' named entity 'oxygen' named entity 'SUBUNIT' named entity 'CHOICE' named entity 'COORDINATE' named entity 'ROLE' named entity 'HOW' named entity 'QUANTITY' named entity 'POTENTIAL' named entity 'DIET SELECTION' named entity 'SYSTEM' named entity 'NUTRIENT' named entity 'ALIGNMENT' named entity 'MAY BE' named entity 'OBESITY' named entity 'CONSIDER' named entity 'APPROPRIATE' named entity 'ADDRESSING' named entity 'LACKS' named entity 'peripheral' named entity 'supply' named entity 'supply' named entity 'AMPK' named entity 'AMP-activated protein kinase' named entity 'obesity' named entity 'rise' named entity 'central' named entity 'central' named entity 'food choice' named entity 'Here' named entity 'potential' named entity 'diet' named entity 'isoforms' named entity 'AMPK' named entity 'food choice' named entity 'AMPK' named entity 'integrated' named entity 'multilocular' named entity 'hypoxaemia' named entity 'leptin' named entity 'pharmacological agents' named entity '2.1' named entity 'phenformin' named entity 'PVN' named entity 'AGRP' named entity 'thyroid hormone' named entity 'hypoxia' named entity 'acclimatisation' named entity 'carbon dioxide levels' named entity 'transferase' named entity 'dorsal and ventral' named entity 'smooth muscle cells' named entity 'AMPK' named entity 'AMP' named entity 'hypoxia' named entity 'AMPK' named entity 'AMPK' named entity 'AMPK' named entity 'biguanide' named entity 'HIF1' named entity 'arousal' named entity 'hypoxia' named entity 'orexigenic' named entity 'HVR' named entity 'tadpole' named entity 'AMP' named entity 'obesity' named entity 'cough' named entity 'energy homeostasis' named entity 'REM' named entity 'AMPK' named entity 'myocytes' named entity 'molecular target' named entity 'gut microbiota' named entity 'AMP' named entity 'high altitude' named entity 'HPV'

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