About: Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein
Creator	Abraham, J Choe, H Demogines, A Farzan, M Sawyer, S
Source	PMC
abstract	Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also facilitates the cellular entry of multiple mammalian viruses. We use evolutionary and functional analyses of TfR1 in the rodent clade, where two families of viruses bind this receptor, to mechanistically dissect how essential housekeeping genes like TFR1 successfully balance the opposing selective pressures exerted by host and virus. We find that while the sequence of rodent TfR1 is generally conserved, a small set of TfR1 residue positions has evolved rapidly over the speciation of rodents. Remarkably, all of these residues correspond to the two virus binding surfaces of TfR1. We show that naturally occurring mutations at these positions block virus entry while simultaneously preserving iron-uptake functionalities, both in rodent and human TfR1. Thus, by constantly replacing the amino acids encoded at just a few residue positions, TFR1 divorces adaptation to ever-changing viruses from preservation of key cellular functions. These dynamics have driven genetic divergence at the TFR1 locus that now enforces species-specific barriers to virus transmission, limiting both the cross-species and zoonotic transmission of these viruses.
has issue date	2013-05-28(xsd:dateTime)
bibo:doi	10.1371/journal.pbio.1001571
bibo:pmid	23723737
has license	cc-by
sha1sum (hex)	dca48fcd1b8a28f470494d64ea3811707e28766b
schema:url	https://doi.org/10.1371/journal.pbio.1001571
resource representing a document's title	Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein
has PubMed Central identifier	PMC3665890
has PubMed identifier	23723737
schema:publication	PLoS Biol
resource representing a document's body	covid:dca48fcd1b8a28f470494d64ea3811707e28766b#body_text
is schema:about of	named entity 'HOUSEKEEPING' named entity 'DUAL' named entity 'ARMS' named entity 'cellular' named entity 'cell-surface receptor' named entity 'essential' named entity 'viruses' named entity 'block' named entity 'binding' named entity 'Shape' named entity 'SHAPE' named entity 'VIRUS' named entity 'PRESERVATION' named entity 'FUNCTIONALITIES' named entity 'GENERALLY' named entity 'THE CELL' named entity 'PROTEIN' named entity 'DRIVEN' named entity 'LIKE' named entity 'RODENT' named entity 'IRON UPTAKE' named entity 'JUST' named entity 'MULTIPLE' covid:arg/dca48fcd1b8a28f470494d64ea3811707e28766b named entity 'VIRUS BINDING' named entity 'VIRUS' named entity 'KEY' named entity 'RECEPTOR' named entity 'MAMMALIAN' named entity 'SELECTIVE' named entity 'PRESSURES' named entity 'RODENTS' named entity 'HAVE' named entity 'ZOONOTIC' named entity 'CONSERVED' named entity 'ESSENTIAL' named entity 'BLOCK' named entity 'VIRUS ENTRY' named entity 'LIMITING' named entity 'SMALL' named entity 'HOST' named entity 'HOST' named entity 'RAPIDLY' named entity 'DISSECT' named entity 'ADAPTATION' named entity 'TRANSMISSION' named entity 'SET' named entity 'USE' named entity 'SURFACE' named entity 'REPLACING' named entity 'DIVORCES' named entity 'EXERTED' named entity 'FUNCTIONS' named entity 'TFR1' named entity 'POSITIONS' named entity 'ENCODED' named entity 'CELLULAR' named entity 'THESE' named entity 'VIRUSES' named entity 'DYNAMICS' named entity 'CONSTANTLY' named entity 'SPECIATION' named entity 'HOUSEKEEPING GENES' named entity 'FAMILIES' named entity 'BIND' named entity 'TRANSFERRIN RECEPTOR' named entity 'UPTAKE' named entity 'ENTRY' named entity 'CROSS' named entity 'FUNCTIONAL' named entity 'CHANGING' named entity 'RESIDUE' named entity 'SPECIFIC' named entity 'CELLS' named entity 'HUMAN' named entity 'WHERE' named entity 'LOCUS'

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