About: Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan
Creator	Chan, Yu-Jiun Fung, Chang-Phone Hwang, Shinn-Jang Lee, Chia-Ling Lee, Shou-Dong Tsai, Cheng-Hsien Wang, Fu-Der Chen, Yi-Ming Yen, David
topic	covid:dcc3b8063446069a3d8e2fb5288f4178d6ce74b9#this
Source	Elsevier; Medline; PMC
abstract	Background The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p = 0.925). Conclusion The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.
has issue date	2010-02-28(xsd:dateTime)
bibo:doi	10.1016/s1726-4901(10)70003-4
bibo:pmid	20171584
has license	els-covid
sha1sum (hex)	dcc3b8063446069a3d8e2fb5288f4178d6ce74b9
schema:url	https://doi.org/10.1016/s1726-4901%2810%2970003-4
resource representing a document's title	Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan
has PubMed Central identifier	PMC7129009
has PubMed identifier	20171584
schema:publication	Journal of the Chinese Medical Association
resource representing a document's body	covid:dcc3b8063446069a3d8e2fb5288f4178d6ce74b9#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/dcc3b8063446069a3d8e2fb5288f4178d6ce74b9
is schema:about of	named entity 'antibodies' named entity 'virus' named entity 'hospital' named entity '2009' named entity 'CAME' named entity 'VACCINATION CAMPAIGN' named entity 'STATUS' named entity 'ANTIVIRAL AGENTS' named entity 'INDIVIDUAL' named entity 'SERUM' named entity 'BASELINE' named entity 'PROPORTION' named entity 'DETERMINE' named entity 'RESULTS' named entity 'MED' named entity 'DIVIDED' named entity '12.6' named entity 'ASSOC' named entity 'HEMAGGLUTINATION' named entity 'CHIN' named entity 'CONTROLLING' named entity 'PANDEMIC' named entity '2.9' named entity 'PHYSICAL' named entity 'UNDERSTAND' named entity 'INFLUENZA' named entity 'ACCORDING' named entity 'CALCULATED' named entity 'POTENTIAL' named entity 'TRANSMISSION' named entity 'TITER' named entity 'VIRUS' named entity '28P' named entity 'SPREAD' named entity 'SEROPOSITIVE' named entity 'APRIL' named entity 'CONTROL GROUPS' named entity 'METHODS' named entity 'PEOPLE' named entity '925' named entity 'THOUGHT' named entity 'YEARS' named entity 'SPECIFIC' named entity 'HIGHER' named entity 'SEX RATIO' named entity 'GROUP' named entity 'DIFFERENT' named entity 'GEOMETRIC MEAN' named entity 'HOSPITAL STAFF' named entity 'MASSIVE' named entity 'INHIBITION' named entity 'VACCINATION' named entity 'SAMPLES' named entity 'VACCINATED' named entity 'CONCLUSION' named entity 'RISK' named entity 'CHECK-UP' named entity 'ITS' named entity 'GENERAL POPULATION' named entity 'RATE' named entity '282' named entity 'INFLUENZA VIRUS' named entity 'PERSONNEL' named entity 'COMPARED' named entity 'SECOND' named entity 'SEROLOGICAL' named entity 'COLLECTED' named entity 'NOVEMBER' named entity 'CONTROL' named entity 'GROUPS' named entity 'TESTS'

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