About: Caerin1.1 Suppresses the Growth of Porcine Epidemic Diarrhea Virus In Vitro via Direct Binding to the Virus

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About: Caerin1.1 Suppresses the Growth of Porcine Epidemic Diarrhea Virus In Vitro via Direct Binding to the Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Caerin1.1 Suppresses the Growth of Porcine Epidemic Diarrhea Virus In Vitro via Direct Binding to the Virus
Creator	He, Qigai Chen, Fangzhou Li, Zhonghua Zhang, Bingzhou Ye, Shiyi Hu, Han Guo, Nan Wang, Chunmei Chen, Pin
Source	Medline; PMC
abstract	Porcine epidemic diarrhea (PED) has re-emerged in recent years and has already caused huge economic losses to the porcine industry all over the world. Therefore, it is urgent for us to find out efficient ways to prevent and control this disease. In this study, the antiviral activity of a cationic amphibian antimicrobial peptide Caerin1.1 against porcine epidemic diarrhea virus (PEDV) was evaluated by an in vitro system using Vero cells. We found that even at a very low concentration, Caerin1.1 has the ability to destroy the integrity of the virus particles to block the release of the viruses, resulting in a considerable decrease in PEDV infections. In addition, Caerin1.1 showed powerful antiviral activity without interfering with the binding progress between PEDV and the receptor of the cells, therefore, it could be used as a potential antiviral drug or as a microbicide compound for prevention and control of PEDV.
has issue date	2018-09-18(xsd:dateTime)
bibo:doi	10.3390/v10090507
bibo:pmid	30231560
has license	cc-by
sha1sum (hex)	dce34f36e8a1d8b4692c1e54852d6942da5d065a
schema:url	https://doi.org/10.3390/v10090507
resource representing a document's title	Caerin1.1 Suppresses the Growth of Porcine Epidemic Diarrhea Virus In Vitro via Direct Binding to the Virus
has PubMed Central identifier	PMC6165370
has PubMed identifier	30231560
schema:publication	Viruses
resource representing a document's body	covid:dce34f36e8a1d8b4692c1e54852d6942da5d065a#body_text
is schema:about of	named entity 'IN VITRO' named entity 'cells' named entity 'antimicrobial peptide' named entity 'GROWTH' named entity 'CONTROL' named entity 'INDUSTRY' named entity 'HUGE' named entity 'SYSTEM' named entity 'FOUND' named entity 'VERY LOW' named entity 'TO PREVENT' named entity 'RECENT' named entity 'EFFICIENT' named entity 'AMPHIBIAN' named entity 'BLOCK' named entity 'ANTIVIRAL ACTIVITY' named entity 'RESULTING IN' named entity 'BINDING' named entity 'LOW CONCENTRATION' named entity 'IN VITRO' named entity 'USED' named entity 'STUDY' named entity 'URGENT' named entity 'PORCINE EPIDEMIC DIARRHEA' named entity 'DISEASE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'USING' named entity 'PREVENTION AND CONTROL' named entity 'INTEGRITY OF' named entity 'SUPPRESSES' named entity 'INTERFERING' named entity 'CELLS' named entity 'ADDITION' named entity 'PORCINE' named entity 'EVALUATED' named entity 'DECREASE' named entity 'COMPOUND' named entity 'POWERFUL' named entity 'VIRUS' named entity 'DIRECT BINDING' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'CAUSED' named entity 'WORLD' named entity 'RELEASE' named entity 'INFECTIONS' named entity 'COULD BE' named entity 'ANTIVIRAL DRUG' named entity 'VERO CELLS' named entity 'PROGRESS' named entity 'VIRUS PARTICLES' named entity 'DESTROY' named entity 'ECONOMIC' named entity 'MICROBICIDE' named entity 'RECEPTOR' named entity 'ANTIMICROBIAL PEPTIDE' named entity 'YEARS' named entity 'CONSIDERABLE' named entity 'VIRUSES' named entity 'POTENTIAL' covid:arg/dce34f36e8a1d8b4692c1e54852d6942da5d065a named entity 'PED' named entity 'addition' named entity 'antiviral' named entity 'system' named entity 'microbicide' named entity 'antiviral activity' named entity 'prevention and control' named entity 'viruses' named entity 'porcine epidemic diarrhea virus' named entity 'antiviral drug' named entity 'amphibian' named entity 'Porcine epidemic diarrhea' named entity 'virus'

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