About: Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish

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About: Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish
Creator	Coll, Julio Estepa, Amparo
Source	Elsevier; Medline; PMC
abstract	Abstract While exploring the molecular mechanisms behind the fin hemorrhages that follow zebrafish (Danio rerio) early infection with viral haemorrhagic septicemia virus (VHSV), we discovered that most serpin (serine protease inhibitor) gene transcripts were upregulated, except those of serpine1. Surprisingly, only SERPINe1-derived 14-mer peptide and low molecular weight drugs targeting SERPINe1 (i.e. tannic acid, EGCG, tiplaxtinin) inhibited in vitro infections not only of VHSV, but also of other fish rhabdoviruses such as infectious hematopoietic necrosis virus (IHNV) and spring viremia carp virus (SVCV). While the mechanisms that inhibited rhabdoviral infections remain speculative, these and other results suggested that SERPINEe1-derived peptide specifically targeted viral infectivity rather than virions. Practical applications might be developed from these studies since preliminary evidences showed that tannic acid could be used to reduce VHSV-caused mortalities. These studies are an example of how the identification of host genes targeted by viral infections using microarrays might facilitate the identification of novel prevention drugs in aquaculture and illuminate viral infection mechanisms.
has issue date	2015-11-30(xsd:dateTime)
bibo:doi	10.1016/j.fsi.2015.09.017
bibo:pmid	26363229
has license	els-covid
sha1sum (hex)	dd2db4b1d209685f16dcff3244c1a142b1b5feb2
schema:url	https://doi.org/10.1016/j.fsi.2015.09.017
resource representing a document's title	Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish
has PubMed Central identifier	PMC7185853
has PubMed identifier	26363229
schema:publication	Fish & Shellfish Immunology
resource representing a document's body	covid:dd2db4b1d209685f16dcff3244c1a142b1b5feb2#body_text
is schema:about of	named entity 'viremia' named entity 'identification' named entity 'DERIVED' named entity 'RATHER' named entity 'TARGETED' named entity 'INFECTIONS' named entity 'PREVENTION' named entity 'EXAMPLE' named entity 'HOST' named entity 'GENE TRANSCRIPTS' named entity 'USING' named entity 'EXPLORING' named entity 'MICROARRAYS' named entity 'VIRAL' named entity 'HOW' named entity 'BUT' named entity 'FOLLOW' named entity 'VHSV' named entity 'LOW MOLECULAR WEIGHT' named entity 'EGCG' named entity 'RHABDOVIRUSES' named entity 'TANNIC ACID' named entity 'NOVEL' named entity 'STUDIES' named entity 'VIRUS' named entity 'IDENTIFICATION' named entity 'VIREMIA' named entity 'GENES' named entity 'TIPLAXTININ' named entity 'RESULTS' named entity 'DRUGS TARGETING' named entity 'EXCEPT' named entity 'THESE' named entity 'USED' named entity 'FIN' named entity 'SPRING' named entity 'VIRAL INFECTIONS' named entity 'AQUACULTURE' named entity 'VIRAL INFECTION' named entity 'INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS' named entity 'CARP' named entity 'HAEMORRHAGIC SEPTICEMIA VIRUS' named entity 'FISH' named entity 'SERPIN' named entity 'SERPINE1' named entity 'MORTALITIES' named entity 'INHIBITED' named entity 'MOLECULAR' named entity 'INFECTIONS' named entity 'ZEBRAFISH' named entity 'INHIBITION' named entity 'SERPINE1' named entity 'DRUGS' named entity 'IN VITRO' named entity 'PRELIMINARY' named entity 'MECHANISMS' named entity 'CAUSED' named entity 'EARLY' named entity 'INFECTIVITY' named entity 'MER' named entity 'INFECTION' named entity 'UPREGULATED' named entity 'VIRIONS' named entity '28I' named entity 'HEMORRHAGES' named entity 'PEPTIDE' named entity 'TO REDUCE' named entity 'PROTEASE INHIBITOR' named entity 'ZEBRAFISH' named entity 'MIGHT BE' named entity 'APPLICATIONS' covid:arg/dd2db4b1d209685f16dcff3244c1a142b1b5feb2 named entity 'studies' named entity 'targeting' named entity 'genes' named entity 'remain' named entity 'virions' named entity 'acid' named entity 'These' named entity 'While'

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