About: Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies

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About: Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies
Creator	Gao, Xiumei Hao, Jia Liu, Erwei Wang, Xingrui Yan, Huo Zhang, Yingyue Zhang, Hao
Source	PMC
abstract	Danhong injection (DHI) is a widely used Chinese Materia Medica standardized product for the clinical treatment of ischemic encephalopathy and coronary heart disease. The bindings of eight natural components in DHI between bovine serum albumin (BSA) were studied by fluorescence spectroscopy technology and molecular docking. According to the results, the quenching process of salvianolic acid B and hydroxysafflor yellow A was a static quenching procedure through the analysis of quenching data by the Stern-Volmer equation, the modified Stern-Volmer equation, and the modified Scatchard equation. Meanwhile, syringin (Syr) enhanced the fluorescence of BSA, and the data were analyzed using the Lineweaver-Burk equation. Molecular docking suggested that all of these natural components bind to serum albumin at the site I location. Further competitive experiments of SaB confirmed the result of molecular docking studies duo to the displacement of warfarin by SaB. Base on these studies, we selected SaB as a research target because it presented the strongest binding ability to BSA and investigated the influence of the multi-components coexisting in DHI on the interaction between the components of the SaB-BSA binding system. The participation of these natural components in DHI affected the interaction between the components of the SaB-BSA system. Therefore, when DHI is used in mammals, SaB is released from serum albumin more quickly than it is used alone. This work would provide a new experiment basis for revealing the scientific principle of compatibility for Traditional Chinese Medicine.
has issue date	2015-06-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0128919
bibo:pmid	26035712
has license	cc-by
sha1sum (hex)	dd4a3353ae21a249a81f30e23fc416a1d948887b
schema:url	https://doi.org/10.1371/journal.pone.0128919
resource representing a document's title	Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies
has PubMed Central identifier	PMC4452768
has PubMed identifier	26035712
schema:publication	PLoS One
resource representing a document's body	covid:dd4a3353ae21a249a81f30e23fc416a1d948887b#body_text
is schema:about of	named entity 'STERN' named entity 'COMPETITIVE' named entity 'BINDINGS' named entity 'DATA' named entity 'THESE' named entity 'SITE' named entity 'NATURAL' named entity 'DUO' named entity 'COMPATIBILITY' named entity 'BURK' named entity 'AFFECTED' named entity 'TARGET' named entity 'COMPONENTS' named entity 'SAB' named entity 'BIND' named entity 'CONFIRMED' named entity 'INTERACTION' named entity 'CLINICAL TREATMENT' named entity 'PARTICIPATION' named entity 'INFLUENCE' named entity 'INJECTION' named entity 'TECHNOLOGY' named entity 'SCIENTIFIC' named entity 'ISCHEMIC ENCEPHALOPATHY' named entity 'CHINESE' named entity 'WAS A' named entity 'WORK' named entity 'SAB' named entity 'bind' named entity 'equation' named entity 'presented' named entity 'serum albumin' named entity 'duo' named entity 'Molecular docking' named entity 'Injection' named entity 'Fluorescence' named entity 'Binding' covid:arg/dd4a3353ae21a249a81f30e23fc416a1d948887b named entity 'BINDING' named entity 'RESULT' named entity 'MOLECULAR DOCKING' named entity 'RESULTS' named entity 'BOVINE SERUM ALBUMIN' named entity 'STUDIES' named entity 'QUENCHING' named entity 'EXPERIMENT' named entity 'LOCATION' named entity 'HYDROXYSAFFLOR YELLOW A' named entity 'SERUM ALBUMIN' named entity 'DISPLACEMENT' named entity 'ANALYZED' named entity 'PRESENTED' named entity 'RESEARCH' named entity 'MODIFIED' named entity 'INVESTIGATED' named entity 'PROCESS' named entity 'FLUORESCENCE' named entity 'DHI' named entity 'BASE' named entity 'MATERIA MEDICA' named entity 'SERUM ALBUMIN' named entity 'DANHONG' named entity 'INJECTION' named entity 'BSA' named entity 'INFLUENCE' named entity 'MOLECULAR DOCKING' named entity 'INTERACTION' named entity 'NATURAL' named entity 'FLUORESCENCE' named entity 'COMPONENTS' named entity 'MULTI' named entity 'ENHANCED' named entity 'ANALYSIS' named entity 'RELEASED' named entity 'TRADITIONAL CHINESE MEDICINE'

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