About: Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion

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About: Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion
Creator	Chen, Yu Bao, Xiaoyong Liu, Shengxuan Ren, Yuping Zhou, Jiehua Deng, Junfang Deng, Xiaoling Prusak, Deborah Wood, Thomas
Source	Elsevier; Medline; PMC
abstract	Abstract Human metapneumovirus (hMPV) is a major cause of lower respiratory infection in young children. Repeated infections occur throughout life, but its immune evasion mechanisms are largely unknown. We recently found that hMPV M2-2 protein elicits immune evasion by targeting mitochondrial antiviral-signaling protein (MAVS), an antiviral signaling molecule. However, the molecular mechanisms underlying such inhibition are not known. Our mutagenesis studies revealed that PDZ-binding motifs, 29-DEMI-32 and 39-KEALSDGI-46, located in an immune inhibitory region of M2-2, are responsible for M2-2-mediated immune evasion. We also found both motifs prevent TRAF5 and TRAF6, the MAVS downstream adaptors, to be recruited to MAVS, while the motif 39-KEALSDGI-46 also blocks TRAF3 migrating to MAVS. In parallel, these TRAFs are important in activating transcription factors NF-kB and/or IRF-3 by hMPV. Our findings collectively demonstrate that M2-2 uses its PDZ motifs to launch the hMPV immune evasion through blocking the interaction of MAVS and its downstream TRAFs.
has issue date	2016-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2016.09.026
bibo:pmid	27743962
has license	els-covid
sha1sum (hex)	dd54e45c61677a09e56a61b0216866c972705d54
schema:url	https://doi.org/10.1016/j.virol.2016.09.026
resource representing a document's title	Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion
has PubMed Central identifier	PMC5102771
has PubMed identifier	27743962
schema:publication	Virology
resource representing a document's body	covid:dd54e45c61677a09e56a61b0216866c972705d54#body_text
is schema:about of	named entity 'IMMUNE EVASION' named entity 'signaling molecule' named entity 'NF-kB' named entity 'Human metapneumovirus' named entity 'infections' named entity 'MAVS' named entity 'adaptors' named entity 'BLOCKS' named entity 'REPEATED INFECTIONS' named entity 'REGION' named entity 'USES' named entity 'A MAJOR' named entity 'OCCUR' named entity 'TRAF5' named entity 'MEDIATED' named entity 'TRAF6' named entity 'IMPORTANT' named entity 'STUDIES' named entity 'THESE' named entity 'BINDING' named entity 'NOT KNOWN' named entity 'BLOCKING' named entity 'ELICITS' named entity 'FUNCTIONAL' named entity 'RESPONSIBLE' named entity 'SIGNALING MOLECULE' named entity 'PDZ' named entity 'TARGETING' named entity 'NF-KB' named entity 'MUTAGENESIS' named entity 'MOTIF' named entity 'M2-2' named entity 'TRAFS' named entity 'LARGELY' named entity 'LOCATED IN' named entity 'UNDERLYING' named entity 'INHIBITION' named entity 'LOWER RESPIRATORY INFECTION' named entity 'PREVENT' named entity 'IMMUNE EVASION' named entity 'RECENTLY' named entity 'ACTIVATING TRANSCRIPTION FACTORS' named entity 'PROTEIN ' named entity 'LIFE' named entity 'UNKNOWN' named entity 'CAUSE' named entity 'FOUND' named entity 'MOTIFS' named entity 'M2-2' named entity 'MEDIATED' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'IS A' named entity 'RESPONSIBLE' named entity 'MOLECULAR' named entity 'OUR' named entity 'MITOCHONDRIAL ANTIVIRAL-SIGNALING PROTEIN' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'BUT' named entity 'MOTIFS' named entity 'ITS' named entity 'MIGRATING' named entity 'TRAF3' named entity 'INHIBITORY' named entity 'YOUNG CHILDREN' named entity 'IMMUNE' named entity 'ANTIVIRAL' named entity 'FINDINGS' named entity 'PARALLEL' named entity 'MECHANISMS' named entity 'INTERACTION' named entity 'MAVS' named entity 'REVEALED' named entity 'IRF-3'

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