About: Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapy

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About: Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapy
Creator	Idris, Fakhriedzwan Diah, • Muharram, Hanna Siti, •
Source	PMC
abstract	Dengue virus, an RNA virus belonging to the genus Flavivirus, affects 50 million individuals annually, and approximately 500,000–1,000,000 of these infections lead to dengue hemorrhagic fever or dengue shock syndrome. With no licensed vaccine or specific antiviral treatments available to prevent dengue infection, dengue is considered a major public health problem in subtropical and tropical regions. The virus, like other enveloped viruses, uses the host’s cellular enzymes to synthesize its structural (C, E, and prM/M) and nonstructural proteins (NS1–5) and, subsequently, to glycosylate these proteins to produce complete and functional glycoproteins. The structural glycoproteins, specifically the E protein, are known to interact with the host’s carbohydrate receptors through the viral proteins’ N-glycosylation sites and thus mediate the viral invasion of cells. This review focuses on the involvement of dengue glycoproteins in the course of infection and the virus’ exploitation of the host’s glycans, especially the interactions between host receptors and carbohydrate moieties. We also discuss the recent developments in antiviral therapies that target these processes and interactions, focusing specifically on the use of carbohydrate-binding agents derived from plants, commonly known as lectins, to inhibit the progression of infection.
has issue date	2016-04-11(xsd:dateTime)
bibo:doi	10.1007/s00705-016-2855-2
bibo:pmid	27068162
has license	no-cc
sha1sum (hex)	dd9f7117ce3bc1640a5c01b2371bdd47912dce85
schema:url	https://doi.org/10.1007/s00705-016-2855-2
resource representing a document's title	Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapy
has PubMed Central identifier	PMC7087181
has PubMed identifier	27068162
schema:publication	Arch Virol
resource representing a document's body	covid:dd9f7117ce3bc1640a5c01b2371bdd47912dce85#body_text
is schema:about of	named entity 'problem' named entity 'RNA virus' named entity 'enzymes' named entity 'glycans' named entity 'The' named entity 'carbohydrate' named entity 'protein' named entity 'glycoproteins' named entity 'interactions' named entity 'CELLS' named entity 'BINDING' named entity 'CELLULAR' named entity 'BELONGING' named entity 'REVIEW' named entity 'KNOWN' named entity 'RECEPTORS' named entity 'FOCUSING' named entity 'DERIVED' named entity 'TO PRODUCE' named entity 'GLYCANS' named entity 'TARGET' named entity 'SUBTROPICAL' named entity 'ITS' named entity 'SPECIFIC' named entity 'LECTINS' named entity 'MEDIATE' named entity 'LICENSED VACCINE' named entity 'PROTEINS' named entity 'E PROTEIN' named entity 'USE OF' named entity 'SYNTHESIZE' named entity 'PUBLIC HEALTH' named entity 'TARGETS' named entity 'VIRUS GLYCOPROTEINS' named entity 'POSSIBLE' named entity 'DEVELOPMENTS' named entity 'HOST' named entity 'FUNCTIONAL' named entity 'TO INHIBIT' named entity 'GENUS FLAVIVIRUS' named entity 'TREATMENTS' named entity 'RECENT' named entity 'CARBOHYDRATE' named entity 'DENGUE SHOCK SYNDROME' named entity 'USES' named entity 'APPROXIMATELY' named entity 'DENGUE INFECTION' named entity 'AVAILABLE' named entity 'DISCUSS' named entity 'ANTIVIRAL' named entity 'LEAD' named entity 'TO INTERACT WITH' named entity 'LIKE' named entity 'TROPICAL REGIONS' named entity 'VIRUSES' named entity 'VIRUS' named entity 'INFECTIONS' named entity 'TO PREVENT' named entity 'STRUCTURAL' named entity 'HEALTH PROBLEM' named entity 'RECEPTORS' named entity 'GLYCOSYLATION' named entity 'CARBOHYDRATE' named entity 'DENGUE' named entity 'NONSTRUCTURAL PROTEINS' named entity 'A MAJOR' named entity 'PLANTS' named entity 'CONSIDERED' named entity 'THESE' named entity 'INTERACTIONS' named entity 'GLYCOPROTEINS' named entity 'ANTIVIRAL THERAPY' named entity 'THEIR' named entity 'PROCESSES' named entity 'THERAPIES' named entity 'INVOLVEMENT' named entity 'COURSE' named entity 'INTERACTIONS'

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