About: Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity
Creator	Camci, Esra Davis, Samantha Raible, David Simon, Julian Wu, Patricia
Source	BioRxiv
abstract	Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is lacking. This study examines the effects of chloroquine on hair cells using two common experimental models: the zebrafish lateral line and neonatal mouse cochlear cultures. Zebrafish larvae were exposed to varying concentrations of chloroquine phosphate or hydroxychloroquine for 1 hr or 24 hr, and hair cells assessed by antibody staining. A significant, dose-dependent reduction in the number of surviving hair cells was seen across conditions for both exposure periods. Hydroxycholroquine showed similar toxicity. In mouse cochlear cultures, chloroquine damage was specific to outer hair cells in tissue from the cochlear basal turn, consistent with susceptibility to other ototoxic agents. These findings suggest a need for future studies employing hearing and balance monitoring during exposure to chloroquine and related compounds, particularly with interest in these compounds as therapeutics against viral infections including coronavirus.
has issue date	2020-04-16(xsd:dateTime)
bibo:doi	10.1101/2020.04.14.041731
has license	biorxiv
sha1sum (hex)	ddbef93b27ebbc2c6d9a68ab35c06d815ea5a802
schema:url	https://doi.org/10.1101/2020.04.14.041731
resource representing a document's title	Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity
schema:publication	bioRxiv
resource representing a document's body	covid:ddbef93b27ebbc2c6d9a68ab35c06d815ea5a802#body_text
is schema:about of	named entity 'Cells' named entity 'Zebrafish' named entity 'toxicity' named entity 'hair cells' named entity 'lateral line' named entity 'ototoxic' named entity 'chloroquine phosphate' named entity 'toxin' named entity 'hair cell' named entity 'chloroquine' named entity 'Zebrafish' named entity 'antibody staining' named entity 'chloroquine' named entity 'quinoline' named entity 'dose-dependent' named entity 'zebrafish' named entity 'toxicity' named entity 'neonatal' named entity 'hair cell' named entity 'ototoxicity' named entity 'experimental models' named entity 'ANOVA' named entity 'chloroquine' named entity 'hair cell' named entity 'chloroquine' named entity 'hair cells' named entity 'chloroquine' named entity 'hair cells' named entity 'Hydroxychloroquine' named entity 'hair cells' named entity 'chloroquine' named entity 'hydroxychloroquine' named entity 'hydroxychloroquine' named entity 'aminoglycoside' named entity 'toxicity' named entity 'chloroquine' named entity 'mechanotransduction' named entity 'outer hair cells' named entity 'dose-response' named entity 'toxicity' named entity 'zebrafish' named entity 'chloroquine' named entity 'Lateral Line' named entity 'Hair Cells' named entity 'Ototoxicity' named entity 'Chloroquine' named entity 'COCHLEAR' named entity 'OTOTOXICITY' named entity 'HAIR CELLS' named entity 'Cultures' named entity 'Zebrafish' named entity 'Lateral' named entity 'Chloroquine' named entity 'Ototoxicity' named entity 'Hair' named entity 'CHLOROQUINE' named entity 'KILLS' named entity 'ZEBRAFISH' named entity 'CULTURES' named entity 'TITLE' named entity 'LATERAL LINE' named entity 'Murine' named entity 'Kills' named entity 'Title' named entity 'Cochlear' named entity 'MURINE'
is part of of	covid:ddbef93b27ebbc2c6d9a68ab35c06d815ea5a802#body_text Chloroquine Kills Hair Cells in Zebrafish Lateral Line and Murine Cochlear Cultures: Implications for Ototoxicity Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is lacking. This study examines the effects of chloroquine on hair cells using two common experimental models: the zebrafish lateral line and neonatal mouse cochlear cultures. Zebrafish larvae were exposed to varying concentrations of chloroquine phosphate or hydroxychloroquine for 1 hr or 24 hr, and hair cells assessed by antibody staining. A significant, dose-dependent reduction in the number of surviving hair cells was seen across conditions for both exposure periods. Hydroxycholroquine showed similar toxicity. In mouse cochlear cultures, chloroquine damage was specific to outer hair cells in tissue from the cochlear basal turn, consistent with susceptibility to other ototoxic agents. These findings suggest a need for future studies employing hearing and balance monitoring during exposure to chloroquine and related compounds, particularly with interest in these compounds as therapeutics against viral infections including coronavirus.

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