About: Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40

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About: Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
Creator	Wang, Zhen Liu, Yonghong Ferreira, Isabel Kaliyaperumal, Kumaravel Lin, Xiu-Ping Qin, Xiao-Chu Tian, Yong-Qi Tu, Zheng-Chao Zhang, Tian-Yu Zhou, Xue-Feng
Source	Medline; PMC
abstract	Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge–derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1–7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC(50) values of 6.2 ± 0.08 and 8.9 ± 0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC(50) value of 3.5 ± 1.3 μM.
has issue date	2015-12-26(xsd:dateTime)
bibo:doi	10.3390/molecules21010034
bibo:pmid	26712735
has license	cc-by
sha1sum (hex)	ddcf8a29af29bdb7e62b35517fef0b0754e59f4f
schema:url	https://doi.org/10.3390/molecules21010034
resource representing a document's title	Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
has PubMed Central identifier	PMC6272915
has PubMed identifier	26712735
schema:publication	Molecules
resource representing a document's body	covid:ddcf8a29af29bdb7e62b35517fef0b0754e59f4f#body_text
is schema:about of	named entity 'determined' named entity 'activity' named entity 'compound' named entity 'PROMINENT' covid:arg/ddcf8a29af29bdb7e62b35517fef0b0754e59f4f named entity 'FUNGUS' named entity '3.5' named entity 'ASTELTOXIN' named entity 'MARINE SPONGE' named entity 'ANTIVIRAL' named entity 'NAMED' named entity 'H1N1' named entity 'DETERMINED BY' named entity '2D-NMR SPECTRA' named entity '981' named entity 'H3N2' named entity 'TESTED FOR' named entity 'SPECTROMETRY' named entity 'ISOLATED' named entity 'MARINE SPONGE' named entity 'ASPERGILLUS SP. SCSIO XWS02F40' named entity 'ACTIVITIES' named entity 'DERIVED' named entity '6.2' named entity 'THEIR' named entity 'ADDITION' named entity 'EXTENSIVE' named entity 'COMPOUND' named entity 'INHIBITORY ACTIVITY' named entity 'KNOWN' named entity 'SIGNIFICANT ACTIVITY' named entity '282' named entity 'DERIVED' named entity 'STRUCTURES' named entity 'ASPERGILLUS SP. SCSIO XWS02F40' named entity 'HRESIMS' named entity 'VALUE' named entity 'CHROMONE' named entity 'NEW' named entity 'VALUES' named entity '283' named entity 'FUNGUS' named entity 'ACTIVITY' named entity 'ANTIVIRAL' named entity 'prominent' named entity 'H3N2' named entity 'structures' named entity 'antiviral' named entity 'marine sponge' named entity 'chromone' named entity 'Aspergillus' named entity 'isolated' named entity 'H3N2' named entity 'inhibitory activity' named entity 'Marine Sponge' named entity 'Two' named entity 'antiviral' named entity 'H1N1' named entity 'Aspergillus' named entity 'fungus' named entity 'Antiviral' named entity 'inhibitory' named entity 'Aspergillus' named entity 'compounds' named entity 'extensive' named entity 'activity' named entity 'compounds' named entity 'compounds' named entity 'H1N1' named entity 'addition' named entity 'chromone' named entity '2D-NMR'

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