About: The clinical pathology of severe acute respiratory syndrome (SARS): a report from China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The clinical pathology of severe acute respiratory syndrome (SARS): a report from China
Creator	Li, Xin Shen, Hong He, Li Ding, Yanqing Cai, Junjie Geng, Jian Han, Huixia Kang, Wei Li, Zhuguo Lu, Yaodan Wang, Huijun Weng, Desheng Wu, Dehua Yao, Kaitai
source	Medline; PMC
abstract	In order to investigate the clinical pathology of severe acute respiratory syndrome (SARS), the autopsies of three patients who died from SARS in Nan Fang Hospital Guangdong, China were studied retrospectively. Routine haematoxylin and eosin (H&E) staining was used to study all of the tissues from the three cases. The lung tissue specimens were studied further with Macchiavello staining, viral inclusion body staining, reticulin staining, PAS staining, immunohistochemistry, ultrathin sectioning and staining, light microscopy, and transmission electron microscopy. The first symptom was hyperpyrexia in all three cases, followed by progressive dyspnoea and lung field shadowing. The pulmonary lesions included bilateral extensive consolidation, localized haemorrhage and necrosis, desquamative pulmonary alveolitis and bronchitis, proliferation and desquamation of alveolar epithelial cells, exudation of protein and monocytes, lymphocytes and plasma cells in alveoli, hyaline membrane formation, and viral inclusion bodies in alveolar epithelial cells. There was also massive necrosis of splenic lymphoid tissue and localized necrosis in lymph nodes. Systemic vasculitis included oedema, localized fibrinoid necrosis, and infiltration of monocytes, lymphocytes, and plasma cells into vessel walls in the heart, lung, liver, kidney, adrenal gland, and the stroma of striated muscles. Thrombosis was present in small veins. Systemic toxic changes included degeneration and necrosis of the parenchyma cells in the lung, liver, kidney, heart, and adrenal gland. Electron microscopy demonstrated clusters of viral particles, consistent with coronavirus, in lung tissue. SARS is a systemic disease that injures many organs. The lungs, immune organs, and systemic small vessels are the main targets of virus attack, so that extensive consolidation of the lung, diffuse alveolar damage with hyaline membrane formation, respiratory distress, and decreased immune function are the main causes of death. Copyright © 2003 John Wiley & Sons, Ltd.
has issue date	2003-07-01(xsd:dateTime)
bibo:doi	10.1002/path.1440
bibo:pmid	12845623
has license	no-cc
sha1sum (hex)	ddec10d6dd3bc15ddd37db380e934c5a8ce9056d
schema:url	https://doi.org/10.1002/path.1440
resource representing a document's title	The clinical pathology of severe acute respiratory syndrome (SARS): a report from China
has PubMed Central identifier	PMC7168017
has PubMed identifier	12845623
schema:publication	J Pathol
resource representing a document's body	covid:ddec10d6dd3bc15ddd37db380e934c5a8ce9056d#body_text
is schema:about of	named entity 'PROGRESSIVE' named entity 'ALVEOLAR' named entity 'FIRST SYMPTOM' covid:arg/ddec10d6dd3bc15ddd37db380e934c5a8ce9056d named entity 'bronchitis' named entity 'light microscopy' named entity 'severe acute respiratory syndrome' named entity 'inclusion body' named entity 'SARS' named entity 'dyspnoea' named entity 'H&E' named entity 'hyperpyrexia' named entity 'staining' named entity 'lung' named entity 'staining' named entity 'staining' named entity 'lung tissue' named entity 'Guangdong' named entity 'PAS' named entity 'infarction' named entity 'clinical pathology' named entity 'diffuse alveolar damage' named entity 'desquamation' named entity 'HIV infection' named entity 'chest radiography' named entity 'inclusion bodies' named entity 'atrophy' named entity 'cytoplasm' named entity 'striated muscles' named entity 'Desquamation' named entity 'hyaline' named entity 'necrosis' named entity 'SER' named entity 'multinucleate' named entity 'clinical symptoms' named entity 'medulla' named entity 'radiographs' named entity 'pulmonary consolidation' named entity 'spleen' named entity 'monocytes' named entity 'necrosis' named entity 'productive cough' named entity 'cardiac muscle' named entity 'lower limbs' named entity 'necrosis' named entity 'white pulp' named entity 'autopsy' named entity 'Alveolar epithelial cells' named entity 'lymphocytes' named entity 'type 2' named entity 'oedema' named entity 'Oedema' named entity 'Guangdong' named entity 'fibrinoid necrosis' named entity 'monocytes' named entity 'necrosis' named entity 'macroscopic' named entity 'demyelination' named entity 'pathogenesis' named entity 'hyaline' named entity 'oedema' named entity 'lymphocytes' named entity 'monocytes' named entity 'oedema' named entity 'CD68' named entity 'Guangdong' named entity 'lymph nodes' named entity 'alveolar epithelial cells'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software