About: Co-Circulation of the Rare CPV-2c with Unique Gln370Arg Substitution, New CPV-2b with Unique Thr440Ala Substitution, and New CPV-2a with High Prevalence and Variation in Heilongjiang Province, Northeast China

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About: Co-Circulation of the Rare CPV-2c with Unique Gln370Arg Substitution, New CPV-2b with Unique Thr440Ala Substitution, and New CPV-2a with High Prevalence and Variation in Heilongjiang Province, Northeast China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Co-Circulation of the Rare CPV-2c with Unique Gln370Arg Substitution, New CPV-2b with Unique Thr440Ala Substitution, and New CPV-2a with High Prevalence and Variation in Heilongjiang Province, Northeast China
Creator	Feng, Li Geng, Yufei Guo, Donghua Li, Chunqiu Su, Mingjun Sun, Dongbo Wang, Enyu Wang, Xinyu Wang, Zhihui Wei, Shan Zhao, Xiwen Wu, Rui Wang, Jianfa Yao, Shuang
Source	Medline; PMC
abstract	To trace evolution of canine parvovirus-2 (CPV-2), a total of 201 stool samples were collected from dogs with diarrhea in Heilongjiang province of northeast China from May 2014 to April 2015. The presence of CPV-2 in the samples was determined by PCR amplification of the VP2 gene (568 bp) of CPV-2. The results revealed that 95 samples (47.26%) were positive for CPV-2, and they showed 98.8%–100% nucleotide identity and 97.6%–100% amino acid identity. Of 95 CPV-2-positive samples, types new2a (Ser297Ala), new2b (Ser297Ala), and 2c accounted for 64.21%, 21.05%, and 14.74%, respectively. The positive rate of CPV-2 and the distribution of the new2a, new2b and 2c types exhibited differences among regions, seasons, and ages. Immunized dogs accounted for 48.42% of 95 CPV-2-positive samples. Coinfections with canine coronavirus, canine kobuvirus, and canine bocavirus were identified. Phylogenetic analysis revealed that the identified new2a, new2b, and CPV-2c strains in our study exhibited a close relationship with most of the CPV-2 strains from China; type new2a strains exhibited high variability, forming three subgroups; type new2b and CPV-2c strains formed one group with reference strains from China. Of 95 CPV-2 strains, Tyr324Ile and Thr440Ala substitutions accounted for 100% and 64.21%, respectively; all type new2b strains exhibited the Thr440Ala substitution, while the unique Gln370Arg substitution was found in all type 2c strains. Recombination analysis using entire VP2 gene indicated possible recombination events between the identified CPV-2 strains and reference strains from China. Our data revealed the co-circulation of new CPV-2a, new CPV-2b, and rare CPV-2c, as well as potential recombination events among Chinese CPV-2 strains.
has issue date	2015-09-08(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0137288
bibo:pmid	26348721
has license	cc-by
sha1sum (hex)	ddf124684188ac29dba3b174f327bd0fd62155bd
schema:url	https://doi.org/10.1371/journal.pone.0137288
resource representing a document's title	Co-Circulation of the Rare CPV-2c with Unique Gln370Arg Substitution, New CPV-2b with Unique Thr440Ala Substitution, and New CPV-2a with High Prevalence and Variation in Heilongjiang Province, Northeast China
has PubMed Central identifier	PMC4562665
has PubMed identifier	26348721
schema:publication	PLoS One
resource representing a document's body	covid:ddf124684188ac29dba3b174f327bd0fd62155bd#body_text
is schema:about of	named entity 'RARE' named entity 'revealed' named entity '2015' named entity 'identified' named entity 'distribution' named entity 'CPV' named entity 'RESULTS' named entity 'CANINE KOBUVIRUS' covid:arg/ddf124684188ac29dba3b174f327bd0fd62155bd named entity 'NUCLEOTIDE' named entity 'HEILONGJIANG PROVINCE' named entity 'DETERMINED BY' named entity 'ENTIRE' named entity 'STUDY' named entity 'CIRCULATION' named entity 'NEW' named entity 'POSITIVE' named entity 'POTENTIAL' named entity 'RECOMBINATION' named entity 'AGES' named entity 'UNIQUE' named entity 'CIRCULATION' named entity 'CPV' named entity 'NORTHEAST' named entity 'APRIL' named entity '100%' named entity 'OUR' named entity 'CANINE CORONAVIRUS' named entity 'HIGH PREVALENCE' named entity 'CHINA' named entity 'NEW' named entity 'GENE' named entity 'ANALYSIS' named entity 'REGIONS' named entity 'VP2' named entity 'USING' named entity 'CHINA' named entity 'IDENTITY' named entity 'SUBGROUPS' named entity 'FORMING' named entity 'POSITIVE RATE' named entity 'CANINE PARVOVIRUS' named entity 'DATA' named entity 'POSSIBLE' named entity 'IDENTIFIED' named entity 'DISTRIBUTION' named entity 'CHINESE' named entity 'EVENTS' named entity 'DOGS' named entity 'FORMED' named entity 'TYPES' named entity 'POSITIVE FOR' named entity 'MOST OF' named entity '2015' named entity 'REFERENCE' named entity 'STOOL' named entity 'SEASONS' named entity 'RARE' named entity 'UNIQUE' named entity 'CPV' named entity 'REVEALED' named entity 'STRAINS' named entity 'PRESENCE OF' named entity 'HIGH VARIABILITY' named entity 'GROUP' named entity 'TYPE' named entity 'CLOSE RELATIONSHIP' named entity 'NORTHEAST'

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