About: COVID‐19 and Vitamin D: A lesson from the skin

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID‐19 and Vitamin D: A lesson from the skin
Creator	Athar, Mohammad Jetten, Anton Holick, Michael Raman, Chander Slominski, Andrzej Slominski, Radomir Stefan, Joanna
Source	Medline; PMC
abstract	The negative outcomes of COVID‐19 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a “cytokine storm” and to the attendant oxidative stress. Active hydroxyl‐forms of vitamin D are anti‐inflammatory, induce anti‐oxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol and the CYP11A1‐generated non‐calcemic hydroxyderivatives. They inhibit the production of pro‐inflammatory cytokines, downregulate NF‐κΒ, show inverse agonism on RORγ and counteract oxidative stress through the activation of NRF‐2. Therefore, a direct delivery of hydroxyderivatives of vitamin D deserves consideration in the treatment of COVID‐19 or ARDS of different etiology. We also recommend treatment of COVID‐19 patients with high dose vitamin D since populations most vulnerable to this disease are likely vitamin D deficient and patients are already under supervision in the clinics. We hypothesize that different routes of delivery (oral and parenteral) will have different impact on the final outcome.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.1111/exd.14170
bibo:pmid	32779213
has license	no-cc
sha1sum (hex)	de03bc2b765ac6bcd22859c2529c8660e6100e48
schema:url	https://doi.org/10.1111/exd.14170
resource representing a document's title	COVID‐19 and Vitamin D: A lesson from the skin
has PubMed Central identifier	PMC7436895
has PubMed identifier	32779213
schema:publication	Exp Dermatol
resource representing a document's body	covid:de03bc2b765ac6bcd22859c2529c8660e6100e48#body_text
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