About: Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

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About: Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques
Creator	Bavari, Sina Palacios, Gustavo Heald, Alison Welch, Lisa Wells, Jay Warren, Travis Iversen, Patrick Nichols, Donald Whitehouse, Chris Charleston, Jay Kugleman, Jeffrey Mattix, Marc
source	Medline; PMC
abstract	Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene, was evaluated as a potential therapeutic intervention for MARV infection following delayed treatment of 1, 24, 48, and 96 h post-infection (PI) in a nonhuman primate lethal challenge model. A total of 30 cynomolgus macaques were divided into 5 groups of 6 and infected with 1,830 plaque forming units of MARV subcutaneously. AVI-7288 was administered by bolus infusion daily for 14 days at 15 mg/kg body weight. Survival was the primary endpoint of the study. While none (0 of 6) of the saline group survived, 83–100% of infected monkeys survived when treatment was initiated 1, 24, 48, or 96 h post-infection (PI). The antisense treatment also reduced serum viremia and inflammatory cytokines in all treatment groups compared to vehicle controls. The antibody immune response to virus was preserved and tissue viral antigen was cleared in AVI-7288 treated animals. These data show that AVI-7288 protects NHPs against an otherwise lethal MARV infection when treatment is initiated up to 96 h PI.
has issue date	2016-02-22(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0004456
bibo:pmid	26901785
has license	cc0
sha1sum (hex)	de0bb38fe24062ae86287891a21a9851a0e6b7f3
schema:url	https://doi.org/10.1371/journal.pntd.0004456
resource representing a document's title	Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques
has PubMed Central identifier	PMC4764691
has PubMed identifier	26901785
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:de0bb38fe24062ae86287891a21a9851a0e6b7f3#body_text
is schema:about of	named entity 'DELAYED TIME' named entity 'MORPHOLINO' named entity 'immune response' named entity 'infection' named entity 'oligomer' named entity 'days' named entity 'OLIGOMER' named entity 'MARBURG VIRUS INFECTION' named entity 'TREATMENT' named entity 'ANTISENSE' named entity 'PRIMARY ENDPOINT' named entity 'TIME-TO-TREATMENT' named entity 'DATA' named entity 'DIVIDED' named entity 'REDUCED' named entity 'SPORADIC' named entity 'INFECTION' named entity 'POST' named entity 'POTENTIAL' named entity 'SALINE' named entity 'GENE' named entity 'VIREMIA' named entity 'DAYS' named entity 'CAUSES' named entity 'CLEARED' named entity 'MONKEYS' named entity 'ANTISENSE' named entity 'LETHAL' named entity 'CYNOMOLGUS' named entity 'VIRAL ANTIGEN' named entity 'NONHUMAN PRIMATE' named entity 'POSITIVELY CHARGED' named entity 'THERAPEUTIC INTERVENTION' named entity 'INFECTED' named entity 'ADMINISTERED' named entity 'GROUPS' named entity 'MACAQUES' named entity 'THESE' named entity 'AVI-7288' named entity 'TARGETING' named entity 'INFLAMMATORY' named entity 'NUCLEOPROTEIN' named entity 'PRESERVED' named entity 'GROUP' named entity 'CYNOMOLGUS' named entity 'FOLLOWING' named entity 'VEHICLE' named entity 'VIRAL' named entity 'PLAQUE FORMING UNITS' named entity 'EVALUATED' named entity 'TISSUE' named entity 'TOTAL' named entity 'RESPONSE TO VIRUS' named entity 'BODY WEIGHT' named entity 'TREATED' named entity 'ANIMALS' named entity 'CASE FATALITY RATE' named entity '90%' named entity 'OUTBREAKS' named entity 'CHALLENGE' named entity 'SURVIVAL' named entity 'MORPHOLINO' named entity 'MG%' named entity 'STUDY' named entity 'HEMORRHAGIC FEVER' named entity 'IMMUNE RESPONSE' named entity 'MODEL' named entity 'HIGH' named entity 'SEVERE' named entity 'DELAYED'

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