About: Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig

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About: Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig
Creator	An, Dong-Jun Jeoung, Hye-Young Jeong, Wooseog Choi, Hwan-Won Lee, Won-Ha Shin, Bo-Hye Lee, Hee
Source	Medline; PMC
abstract	BACKGROUND: In this study, porcine encephalomyocarditis virus (EMCV) virus-like particles (VLPs) were generated using a baculovirus expression system and were tested for immunogenicity and protective efficacy in vivo. RESULTS: VLPs were successfully generated from Sf9 cells infected with recombinant baculovirus and were confirmed to be approximately 30-40 nm by transmission electron microscopy (TEM). Immunization of mice with 0.5 μg crude protein containing the VLPs resulted in significant protection from EMCV infection (90%). In swine, increased neutralizing antibody titers were observed following twice immunization with 2.0 μg crude protein containing VLPs. In addition, high levels of neutralizing antibodies (from 64 to 512 fold) were maintained during a test period following the second immunization. No severe injection site reactions were observed after immunization and all swine were healthy during the immunization period CONCLUSION: Recombinant EMCV VLPs could represent a new vaccine candidate to protect against EMCV infection in pig farms.
has issue date	2011-04-15(xsd:dateTime)
bibo:doi	10.1186/1743-422x-8-170
bibo:pmid	21492483
has license	cc-by
sha1sum (hex)	de793a20bfe9029e76531469de1054c4d5ef37c7
schema:url	https://doi.org/10.1186/1743-422x-8-170
resource representing a document's title	Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig
has PubMed Central identifier	PMC3119933
has PubMed identifier	21492483
schema:publication	Virol J
resource representing a document's body	covid:de793a20bfe9029e76531469de1054c4d5ef37c7#body_text
is schema:about of	named entity 'PORCINE' named entity 'porcine' named entity 'ENCEPHALOMYOCARDITIS VIRUS' named entity 'EFFICACY' named entity 'STUDY' named entity 'TESTED FOR' named entity 'PORCINE' named entity 'ENCEPHALOMYOCARDITIS VIRUS' named entity 'IMMUNOGENICITY' covid:arg/de793a20bfe9029e76531469de1054c4d5ef37c7 named entity 'SAFETY' named entity 'VIRUS-LIKE PARTICLE' named entity 'GENERATED' named entity 'BACKGROUND' named entity 'USING' named entity 'VIRUS-LIKE PARTICLES' named entity 'BACULOVIRUS EXPRESSION SYSTEM' named entity 'PIG' named entity 'IMMUNOGENICITY' named entity 'IN VIVO' named entity 'safety' named entity 'virus-like particles' named entity 'vaccination' named entity 'uranyl acetate' named entity 'protease' named entity 'antibodies' named entity 'baculovirus' named entity 'VLPs' named entity 'porcine' named entity 'VLPs' named entity 'EMCV' named entity 'vaccine' named entity 'VLPs' named entity 'mice' named entity 'immunization' named entity 'neutralizing antibodies' named entity 'baculoviruses' named entity 'genome' named entity 'humoral immune response' named entity 'Recombinant' named entity 'Recombinant' named entity 'Sf9' named entity 'vaccine' named entity 'VLPs' named entity 'ANOVA' named entity 'hydrolysate' named entity 'EMCV' named entity 'Sf9' named entity 'VLPs' named entity 'Korea' named entity 'acute myocarditis' named entity 'clinical signs' named entity 'PCR' named entity 'baculovirus' named entity 'polyethylene glycol' named entity 'Invitrogen' named entity 'hepatitis B virus' named entity 'crude protein' named entity 'immunization' named entity 'TEM' named entity 'kDa' named entity 'cytoplasmic' named entity 'antimycotic' named entity 'Picornaviridae' named entity 'VP1' named entity 'immunization' named entity 'rotavirus' named entity '2.0' named entity 'EMCV' named entity 'EMCV' named entity 'PBS' named entity 'France' named entity 'staining' named entity 'neutralizing antibodies' named entity 'CD4'

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