About: Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
Creator	Schwartz, Robert Oishi, Kohei Liu, Wen-Chun Albrecht, Randy Jordan, Tristan Lim, Jean Tenoever, Benjamin Blanco-Melo, Daniel Hoagland, Daisy Møller, Rasmus Nilsson-Payant, Benjamin Panis, Maryline Sachs, David Uhl, Skyler Wang, Taia
Source	Elsevier; Medline; PMC
abstract	Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.04.026
bibo:pmid	32416070
has license	no-cc
sha1sum (hex)	dea4b05ab91f7eb501a9205c53c2f510bdccf147
schema:url	https://doi.org/10.1016/j.cell.2020.04.026
resource representing a document's title	Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
has PubMed Central identifier	PMC7227586
has PubMed identifier	32416070
schema:publication	Cell
resource representing a document's body	covid:dea4b05ab91f7eb501a9205c53c2f510bdccf147#body_text
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