About: Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins

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About: Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins
Creator	Viuff, Birgitte Knud, Herby Krogh Nielsen, Thomas Larsen, Lars Nielsen, Se Uttenthal, A Stege Philipsen, Jens Tjùrnehùj, Kirsten
Source	Elsevier; Medline; PMC
abstract	Using specific ELISAs, antibody levels of four different isotypes to bovine respiratory syncytial virus (BRSV) were determined in calves, following experimental BRSV infection. Most calves experienced an increase in the specific IgM and IgG1 titres about 6–10 days after infection with BRSV. The IgM titre was transient showing positive titres for only 5–10 days, while specific IgG1 was present for a longer time. IgA was detected concomitantly with IgM but at a lower level. Production of IgG2 anti-BRSV antibodies was detected from 3 weeks after infection. In two closed herds, repeated blood samplings were performed on young stock to analyse maternal immunity. The passively transferred antibodies were mainly of the IgG1 isotype and the half-life of IgG1 to BRSV was estimated to be 26.6 days. One of the herds had an outbreak of enzootic pneumonia, diagnosed to be caused by BRSV. Furthermore, another herd with acute BRSV was followed by weekly blood samples in six calves; in both herds IgM and IgG1 was detected shortly after the appearance of clinical signs. Serum samples from 50 Danish dairy herds (453 samples) were tested for immunoglobulins of the isotypes IgG1, IgG2 and IgM. The presence of antibodies to BRSV was widespread and more than 54% of the samples had BRSV antibodies of both the IgG1 and IgG2 isotypes indicating a high herd prevalence to BRSV. Test samples from two herds out of 50 were free from all isotypes to BRSV.
has issue date	2000-10-20(xsd:dateTime)
bibo:doi	10.1016/s0378-1135(00)00261-3
bibo:pmid	11000530
has license	no-cc
sha1sum (hex)	dec3bae21563da31f703012a5a4920e0e854ae4c
schema:url	https://doi.org/10.1016/s0378-1135%2800%2900261-3
resource representing a document's title	Antibody dynamics in BRSV-infected Danish dairy herds as determined by isotype-specific immunoglobulins
has PubMed Central identifier	PMC7117174
has PubMed identifier	11000530
schema:publication	Vet Microbiol
resource representing a document's body	covid:dec3bae21563da31f703012a5a4920e0e854ae4c#body_text
is schema:about of	named entity 'experimental' named entity 'DYNAMICS' named entity 'AEC' named entity 'LEVELS' named entity 'CALVES' named entity 'INFECTION' named entity 'EXPERIMENTAL' named entity 'ISOTYPES' named entity 'BRSV' named entity 'DETERMINED' named entity 'ELISAS' named entity 'IMMUNOGLOBULINS' named entity 'ANTIBODY' named entity 'ISOTYPE' named entity 'DETERMINED BY' named entity 'INFECTED' named entity 'DANISH' named entity 'DAIRY' named entity 'BOVINE RESPIRATORY SYNCYTIAL VIRUS' named entity 'DIFFERENT' named entity 'USING' named entity 'BRSV' named entity 'AEC' named entity 'FOLLOWING' named entity 'ANTIBODY' covid:arg/dec3bae21563da31f703012a5a4920e0e854ae4c named entity 'speci' named entity 'isotypes' named entity 'Danish' named entity 'Antibody' named entity 'serum' named entity 'antibodies' named entity 'Danish' named entity 'antigen' named entity 'IgA' named entity 'heifers' named entity 'IgM' named entity 'lung lavage' named entity 'antigen' named entity 'Denmark' named entity 'infection' named entity 'IgM' named entity 'IgG1' named entity 'colostrum' named entity 'IgA' named entity 'IgG1' named entity 'IgG2' named entity 'antibodies' named entity 'infection' named entity 'IgG1' named entity 'antibodies' named entity 'enzyme' named entity 'serum samples' named entity 'IgG2' named entity 'Bovine' named entity 'PID' named entity 'serum' named entity 'clinical signs' named entity 'antibodies' named entity 'IgG1' named entity 'IgM' named entity 'IgG1' named entity 'cattle' named entity 'Denmark' named entity 'antibodies' named entity 'Serum samples' named entity 'IgG antibodies' named entity 'PID' named entity 'IgG1' named entity 'Colostrum' named entity 'PBS' named entity 'isotypes' named entity 'completely free' named entity 'virus'

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