About: Antiviral activity of itraconazole against type I feline coronavirus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activity of itraconazole against type I feline coronavirus infection
Creator	Hohdatsu, Tsutomu Doki, Tomoyoshi Takano, Tomomi Akiyama, Misuzu
Source	Medline; PMC
abstract	Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70–90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.
has issue date	2019-01-18(xsd:dateTime)
bibo:doi	10.1186/s13567-019-0625-3
bibo:pmid	30658691
has license	cc-by
sha1sum (hex)	dedff395d93d8023667fc500d7c7c8451d581451
schema:url	https://doi.org/10.1186/s13567-019-0625-3
resource representing a document's title	Antiviral activity of itraconazole against type I feline coronavirus infection
has PubMed Central identifier	PMC6339390
has PubMed identifier	30658691
schema:publication	Vet Res
resource representing a document's body	covid:dedff395d93d8023667fc500d7c7c8451d581451#body_text
is schema:about of	named entity 'itraconazole' named entity 'feline coronavirus' named entity 'WORLDWIDE' named entity 'SEVERE' named entity 'DOMINANT' named entity 'DEMONSTRATED' named entity 'ANTIVIRAL' named entity 'FIP' named entity 'INFECTIOUS PERITONITIS' named entity 'THERAPEUTIC' named entity 'DOMESTIC' named entity 'ITRACONAZOLE' named entity 'TO PROVIDE' named entity 'FUNGAL INFECTIONS' named entity 'TYPE I' named entity 'WILD' named entity 'SEROTYPES' named entity 'FELINE' named entity 'STUDY' named entity 'NECESSARY' named entity 'CAUSATIVE AGENTS' named entity 'SYSTEMIC DISEASE' named entity '90%' named entity 'ANTIVIRAL ACTIVITY' named entity 'TYPE I' named entity 'SEROTYPE' named entity 'ITRACONAZOLE' named entity 'FELINE CORONAVIRUS' named entity 'CORONAVIRUS INFECTION' named entity 'CELLS' named entity 'ANTIVIRAL AGENTS' named entity 'HAVE' named entity 'CORONAVIRUSES' named entity 'VIRAL INFECTION' named entity 'USED' named entity 'CLASSIFIED' named entity 'CATS' named entity 'INFECTION' named entity 'EFFECT' covid:arg/dedff395d93d8023667fc500d7c7c8451d581451 named entity 'infection' named entity 'filipin' named entity 'FIPV' named entity 'FCoV' named entity 'type II' named entity 'cytotoxic effects' named entity 'virus' named entity 'Felis catus' named entity 'virus' named entity 'plaque formation' named entity 'fungal infections' named entity 'cats' named entity 'itraconazole' named entity 'Antiviral activity' named entity 'infection' named entity 'itraconazole' named entity 'systemic disease' named entity 'infection' named entity 'intracellular' named entity 'virus' named entity 'antiviral' named entity '37 °C' named entity '2-phenylindole' named entity '37 °C' named entity 'Cytotoxicity' named entity 'Japan' named entity 'OSBP' named entity 'FIPV' named entity 'infection' named entity 'FCoV' named entity 'cholesterol' named entity 'veterinarians' named entity 'vaccines' named entity 'infection' named entity 'fungal infection' named entity 'infectivity' named entity 'infection' named entity 'serotypes'

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