About: No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs

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About: No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs
Creator	Hall, Richard Carraway, Joseph Gazda, Lawrence Laramore, Melissa Smith, Barry Vinerean, Horatiu
Source	Medline; PMC
abstract	We have previously described the use of a double coated agarose-agarose porcine islet macrobead for the treatment of type I diabetes mellitus. In the current study, the long-term viral safety of macrobead implantation into pancreatectomized diabetic dogs treated with pravastatin (n = 3) was assessed while 2 dogs served as nonimplanted controls. A more gradual return to preimplant insulin requirements occurred after a 2nd implant procedure (days 148, 189, and >652) when compared to a first macrobead implantation (days 9, 21, and 21) in all macrobead implanted animals. In all three implanted dogs, porcine C-peptide was detected in the blood for at least 10 days following the first implant and for at least 26 days following the second implant. C-peptide was also present in the peritoneal fluid of all three implanted dogs at 6 months after 2nd implant and in 2 of 3 dogs at necropsy. Prescreening results of islet macrobeads and culture media prior to transplantation were negative for 13 viruses. No evidence of PERV or other viral transmission was found throughout the study. This study demonstrates that the long-term (2.4 years) implantation of agarose-agarose encapsulated porcine islets is a safe procedure in a large animal model of type I diabetes mellitus.
has issue date	2014-06-05(xsd:dateTime)
bibo:doi	10.1155/2014/727483
bibo:pmid	24995342
has license	cc-by
sha1sum (hex)	df5401bebedec1ea63a7afebb3b4166f775fbd82
schema:url	https://doi.org/10.1155/2014/727483
resource representing a document's title	No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs
has PubMed Central identifier	PMC4068064
has PubMed identifier	24995342
schema:publication	J Diabetes Res
resource representing a document's body	covid:df5401bebedec1ea63a7afebb3b4166f775fbd82#body_text
is schema:about of	named entity 'study' named entity 'porcine' named entity 'islets' named entity 'C-peptide' named entity 'coated' named entity 'implant' named entity 'Porcine' named entity 'Transmission' named entity 'VIRAL TRANSMISSION' named entity 'DOGS' covid:arg/df5401bebedec1ea63a7afebb3b4166f775fbd82 named entity 'IMPLANT' named entity 'COATED' named entity 'PRESENT' named entity 'DETECTED' named entity 'DOUBLE' named entity 'DIABETIC' named entity 'DOGS' named entity 'BLOOD' named entity 'LONG-TERM' named entity 'IMPLANTATION' named entity 'COMPARED' named entity 'VIRUSES' named entity 'USE OF' named entity 'NEGATIVE' named entity 'RETURN TO' named entity 'GRADUAL' named entity 'ASSESSED' named entity 'SAFE' named entity 'PROCEDURE' named entity 'SECOND' named entity 'YEARS' named entity 'STUDY' named entity 'MODEL OF' named entity 'CURRENT' named entity 'VIRAL SAFETY' named entity 'CULTURE MEDIA' named entity 'ISLET' named entity 'PORCINE' named entity '282' named entity 'DESCRIBED' named entity 'REQUIREMENTS' named entity 'PRAVASTATIN' named entity 'TYPE I DIABETES MELLITUS' named entity 'TREATMENT' named entity 'OCCURRED' named entity '2ND' named entity 'PRIOR TO' named entity 'IMPLANTATION' named entity 'LONG-TERM' named entity 'NO EVIDENCE OF' named entity 'AGAROSE' named entity 'PREVIOUSLY' named entity 'ENCAPSULATED' named entity 'FOLLOWING' named entity 'DAYS' named entity 'IS A' named entity 'IMPLANTED' named entity 'TRANSPLANTATION' named entity 'RESULTS' named entity 'VIRAL TRANSMISSION' named entity '189' named entity 'LARGE' named entity '2 OF 3' named entity 'DIABETIC' named entity 'AGAROSE' named entity 'ANIMAL MODEL' named entity 'NO EVIDENCE OF' named entity 'NECROPSY' named entity 'PRESCREENING' named entity 'FOLLOWING' named entity 'ENCAPSULATED' named entity 'TREATED WITH' named entity 'C-PEPTIDE' named entity 'PORCINE' named entity 'HAVE'

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