About: Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis

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About: Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis
Creator	Beitland, Sigrid Berit Guttormsen, Anne Folkestad, Torgeir Gundro Brurberg, Kjetil Nordhuus, Kine Os, Ingrid Tveiten, Christine
Source	PMC
abstract	BACKGROUND: Acute kidney injury (AKI) is a common complication in burn patients admitted to the intensive care unit (ICU) associated with increased morbidity and mortality. Our primary aim was to review incidence, risk factors, and outcomes of AKI in burn patients admitted to the ICU. Secondary aims were to review the use of renal replacement therapy (RRT) and impact on health care costs. METHODS: We conducted a systematic search in PubMed, UpToDate, and NICE through 3 December 2018. All reviews in Cochrane Database of Systematic Reviews except protocols were added to the PubMed search. We searched for studies on AKI according to Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE); Acute Kidney Injury Network (AKIN); and/or Kidney Disease: Improving Global Outcomes (KDIGO) criteria in burn patients admitted to the ICU. We collected data on AKI incidence, risk factors, use of RRT, renal recovery, length of stay (LOS), mortality, and health care costs. RESULTS: We included 33 observational studies comprising 8200 patients. Overall study quality, scored according to the Newcastle-Ottawa scale, was moderate. Random effect model meta-analysis revealed that the incidence of AKI among burn patients in the ICU was 38 (30–46) %. Patients with AKI were almost evenly distributed in the mild, moderate, and severe AKI subgroups. RRT was used in 12 (8–16) % of all patients. Risk factors for AKI were high age, chronic hypertension, diabetes mellitus, high Total Body Surface Area percent burnt, high Abbreviated Burn Severity Index score, inhalation injury, rhabdomyolysis, surgery, high Acute Physiology and Chronic Health Evaluation II score, high Sequential Organ Failure Assessment score, sepsis, and mechanical ventilation. AKI patients had 8.6 (4.0–13.2) days longer ICU LOS and higher mortality than non-AKI patients, OR 11.3 (7.3–17.4). Few studies reported renal recovery, and no study reported health care costs. CONCLUSIONS: AKI occurred in 38% of burn patients admitted to the ICU, and 12% of all patients received RRT. Presence of AKI was associated with increased LOS and mortality. TRIAL REGISTRATION: PROSPERO (CRD42017060420)
has issue date	2020-01-02(xsd:dateTime)
bibo:doi	10.1186/s13054-019-2710-4
bibo:pmid	31898523
has license	cc-by
sha1sum (hex)	dfbc39af0a5845b6f3698657c81a4527a45a4021
schema:url	https://doi.org/10.1186/s13054-019-2710-4
resource representing a document's title	Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis
has PubMed Central identifier	PMC6941386
has PubMed identifier	31898523
schema:publication	Crit Care
resource representing a document's body	covid:dfbc39af0a5845b6f3698657c81a4527a45a4021#body_text
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