About: EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: novel propositions

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About: EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: novel propositions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: novel propositions
Creator	Balaji, Madapusi Bds, ( Gadbail, Amol Gondivkar, Shailesh Patil G (bds, Shankargouda Patil, Shankargouda Sachin, C Sarode, Gargi Sarode, Sachin Sarode, Sharma, Nilesh Varadarajan, Saranya
Source	Elsevier; Medline; PMC
abstract	Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPRIN, has been regarded as a target for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attachment and entry into the host cell. Since one of the routes of entry for the virus is the oral cavity, it becomes imperative to percept oral comorbidities such oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) in terms of EMMPRIN as a target for SARS-CoV-2. In the present paper, it is proposed that OSCC, by the virtue of upregulation of EMMPRIN expression, increases the susceptibility to coronavirus disease (COVID-19). In turn, COVID-19 in OSCC patients causes exhaustion of EMMPRIN receptor due to binding with ‘S’ receptor leading to a downregulation of related carcinogenesis events. We proposed that in the ACE-2 depleted situation in OSCC, EMMPRIN receptor might get high jacked by the COVID-19 virus for the entry into the host cells. Apart from the anti-monoclonal antibody, it is recommended to explore the use of grape seed and skin containing mouthwash as an adjunct, which could also have anti EMMPRIN effects in patients with OSCC and OPMDs.
has issue date	2020-07-09(xsd:dateTime)
bibo:doi	10.1016/j.mehy.2020.110089
bibo:pmid	32673940
has license	no-cc
sha1sum (hex)	dff9cc9db22e6af74b4d384e0ccc8d009b41ef0a
schema:url	https://doi.org/10.1016/j.mehy.2020.110089
resource representing a document's title	EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: novel propositions
has PubMed Central identifier	PMC7346812
has PubMed identifier	32673940
schema:publication	Med Hypotheses
resource representing a document's body	covid:dff9cc9db22e6af74b4d384e0ccc8d009b41ef0a#body_text
is schema:about of	named entity 'imperative' named entity 'downregulation' named entity 'adjunct' named entity 'patients' named entity 'events' named entity 'Extracellular matrix' named entity 'matrix metalloproteinase' named entity 'comorbidities' named entity 'oral squamous cell carcinoma' named entity 'COMORBIDITIES' named entity 'HOST CELLS' named entity 'EMMPRIN' named entity 'EFFECTS' named entity 'CONTAINING' named entity 'SIGNIFICANT' named entity 'ORAL POTENTIALLY MALIGNANT DISORDERS' named entity 'CELL SURFACE' named entity 'RECOGNITION' named entity 'CORONAVIRUS DISEASE' named entity 'SITUATION' named entity 'immunology' named entity 'grape seed' named entity 'receptor' named entity 'paper' named entity 'surface' named entity 'SARS-CoV-2' named entity 'BASIGIN' named entity 'EMMPRIN' named entity 'matrix metalloproteinase' named entity 'OSCC' named entity 'receptor' named entity 'downregulation' named entity 'receptor' named entity 'virus' named entity 'OSCC' named entity 'host cells' named entity 'upregulation' named entity 'EMMPRIN' named entity 'ACE' named entity 'mouthwashes' named entity 'humanized antibody' named entity 'COVID-19' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'receptor' named entity 'protein' named entity 'ACE2' named entity 'glycoprotein' named entity 'molecular level' named entity 'EMMPRIN' named entity 'tumor cells' named entity 'OSMF' named entity 'host cells' named entity 'tobacco' named entity 'receptor' named entity 'Metabolic' named entity 'vascular endothelial growth factors' named entity 'periodontitis' named entity 'COVID-19 infection' named entity 'SARS-CoV-2' named entity 'virus' named entity 'ACE-2' named entity 'betel nut' named entity 'SARS-CoV-2' named entity 'comorbidities' named entity 'antibody' named entity 'meta-analysis' named entity 'EMMPRIN' named entity 'EMMPRIN' named entity 'tumor microenvironment'

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