About: Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing

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About: Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing
Creator	Muir, Peter Vipond, Barry Christensen, Hannah Thornton, Hannah Blair, Peter Hay, Alastair Leeming, John Lovering, Andrew Peters, Tim Redmond, Niamh Turnbull, Sophie
topic	covid:e04e77c0564ec2ccd37586cee5d3a09abca82597#this
Source	Medline; PMC
abstract	BACKGROUND AND OBJECTIVES. Diagnostic uncertainty over respiratory tract infections (RTIs) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. If symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. This study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs. METHODS. Cross-sectional study of children ≥3 months to <16 years presenting with acute cough and RTI, with subset follow-up. Associations and area under receiver operating curve (AUROC) statistics sought between clinical presentation and baseline microbe detection. Microbe prevalence compared between baseline (symptomatic) and follow-up (asymptomatic) visits. RESULTS. At baseline, ≥1 bacteria was detected in 1257/2113 (59.5%) children and ≥1 virus in 894/2127 (42%) children. Clinical presentation was not associated with detection of ≥1 bacteria [AUROC 0.54 (95% CI 0.52–0.56)] or ≥1 virus [0.64 (95% CI 0.61–0.66)]. Individually, only respiratory syncytial virus (RSV) was associated with clinical presentation [AUROC 0.80 (0.77–0.84)]. Prevalence fell between baseline and follow-up; more so in viruses (68% versus 26%, P < 0.001) than bacteria (56% versus 40%, P = 0.01); greatest reductions seen in RSV, influenza B and Haemophilus influenzae. CONCLUSION. Findings demonstrate that clinical presentation cannot distinguish the presence of bacteria or viruses in the upper respiratory tract. However, individual and overall microbe prevalence was greater when children were unwell than when well, providing some evidence that upper respiratory tract microbes may be the cause or consequence of the illness. If causal, selective microbial point-of-care testing could be beneficial.
has issue date	2017-02-18(xsd:dateTime)
bibo:doi	10.1093/fampra/cmw136
bibo:pmid	28334924
has license	cc-by-nc
sha1sum (hex)	e04e77c0564ec2ccd37586cee5d3a09abca82597
schema:url	https://doi.org/10.1093/fampra/cmw136
resource representing a document's title	Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing
has PubMed Central identifier	PMC7108458
has PubMed identifier	28334924
schema:publication	Fam Pract
resource representing a document's body	covid:e04e77c0564ec2ccd37586cee5d3a09abca82597#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/e04e77c0564ec2ccd37586cee5d3a09abca82597
is schema:about of	named entity 'DETECTION' named entity 'ASSOCIATIONS' named entity 'FINDINGS' named entity 'REDUCTIONS' named entity 'INFLUENZA B' named entity 'CURVE' named entity 'DETECTED' named entity 'DIAGNOSTIC' named entity 'STATISTICS' named entity 'ANTIBIOTIC RESISTANCE' named entity 'VIRUS' named entity '0.01' named entity 'MAY BE' named entity 'PRESENCE OF BACTERIA' named entity 'MICROBE' named entity 'GREATER' named entity 'FELL' named entity 'MONTHS' named entity 'OBJECTIVES' named entity 'FOLLOW-UP' named entity '2859' named entity 'OPERATING' named entity 'INDIVIDUAL' named entity 'CHILDREN' named entity 'RTI' named entity 'SUBSET' named entity 'virus' named entity 'receiver' named entity 'acute' named entity 'microbiology' named entity 'RSV' named entity 'symptoms' named entity 'TARGETS' named entity 'UPPER RESPIRATORY TRACT' named entity 'METHODS' named entity 'THROAT' named entity 'CLINICAL PRESENTATION' named entity 'GREATEST' named entity 'PREDICT' named entity 'ASSOCIATED WITH' named entity 'BENEFICIAL' named entity 'RESPIRATORY TRACT' named entity 'ANTIBIOTICS' named entity 'OVERALL' named entity 'CONSEQUENCE OF' named entity 'COMPARED' named entity 'BACTERIA ' named entity 'RELATIONSHIPS' named entity 'VISITS' named entity 'SYMPTOMS AND SIGNS' named entity 'ACUTE COUGH' named entity 'POTENTIAL' named entity 'POINT-OF-CARE TESTING' named entity 'ASSOCIATIONS' named entity 'RESPIRATORY TRACT INFECTION' named entity 'THROAT' named entity 'HELP' named entity 'VIRUSES' named entity '0.001' named entity 'UNWELL' named entity 'A51' named entity 'CONCLUSION' named entity 'YEARS' named entity 'MICROBES' named entity 'AREA' named entity 'EVIDENCE' named entity 'RECEIVER' named entity 'MICROBIAL' named entity 'CAUSE'

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