About: RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling
Creator	Jones, Kevin Althaus, J Carlos, Jean Chen, Alex Díaz, Rodríguez Garay, Patricia Giger, Roman Iwase, Shigeki Kohen, Rafi Sutton, Michael Tsukahara, Takao Wallner, Margarete
Source	PMC
abstract	Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing to profile transcriptional dynamics of primary neuron cultures undergoing network activity shifts. We find pervasive transcriptional changes, in which ∼45% of expressed genes respond to network activity shifts. We further link retinoic acid-induced 1 (RAI1), the Smith-Magenis syndrome gene, to the transcriptional program driven by reduced network activity. Remarkable agreement among nascent transcriptomes, dynamic chromatin occupancy of RAI1, and electrophysiological properties of Rai1-deficient neurons demonstrates the essential roles of RAI1 in suppressing synaptic upscaling in the naive network, while promoting upscaling triggered by activity silencing. These results highlight the utility of bona fide transcription profiling to discover mechanisms of activity-dependent chromatin remodeling that underlie normal and pathological synaptic plasticity.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2020.108002
has license	no-cc
sha1sum (hex)	e07a68e06cf2c33ce5f58c9a0af10e3edd8e906e
schema:url	https://doi.org/10.1016/j.celrep.2020.108002
resource representing a document's title	RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling
has PubMed Central identifier	PMC7418709
schema:publication	Cell Rep
resource representing a document's body	covid:e07a68e06cf2c33ce5f58c9a0af10e3edd8e906e#body_text
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