About: Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm

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About: Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm
Creator	Shoenfeld, Yehuda Lucas, Rudolf Giacomelli, Roberto Ruscitti, Piero Berardicurti, Onorina Cipriani, Paola Iagnocco, Annamaria Benedetto, Paola Iván Valdés-Ferrer, Sergio Zubirán, Salvador
Source	Medline; PMC
abstract	The coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been declared as a worldwide public health emergency. Interestingly, severe COVID-19 is characterized by fever, hyperferritinemia, and a hyper-inflammatory process with a massive release of pro-inflammatory cytokines, which may be responsible for the high rate of mortality. These findings may advocate for a similarity between severe COVID-19 and some challenging rheumatic diseases, such as adult onset Still's disease, secondary hemophagocytic lymphohistiocytosis, and catastrophic anti-phospholipid syndrome, which have been included in the “hyperferritinemic syndrome” category. Furthermore, as performed in these hyper-inflammatory states, severe COVID-19 may benefit from immunomodulatory therapies.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01130
bibo:pmid	32574264
has license	cc-by
sha1sum (hex)	e0e72f47f5a66583bd94c58e8a48d2f604473a14
schema:url	https://doi.org/10.3389/fimmu.2020.01130
resource representing a document's title	Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm
has PubMed Central identifier	PMC7270352
has PubMed identifier	32574264
schema:publication	Front Immunol
resource representing a document's body	covid:e0e72f47f5a66583bd94c58e8a48d2f604473a14#body_text
is schema:about of	named entity 'COVID-19' named entity 'MINI' named entity 'Syndrome' named entity 'ligation' named entity 'hematopoietic cells' named entity 'CXCL10' named entity 'COVID-19' named entity 'cytosolic' named entity 'pro-inflammatory' named entity 'COVID' named entity 'high levels' named entity 'IL-1β' named entity 'interferon regulatory factor 3' named entity 'inflammatory response' named entity 'multiple organ dysfunction syndrome' named entity 'immunomodulatory' named entity 'lymphocytes' named entity 'ferritin' named entity 'lung' named entity 'macrophages' named entity 'hepatic' named entity 'janus kinase' named entity 'IL-6' named entity 'viral load' named entity 'IFN-γ' named entity 'SJIA' named entity 'HLH' named entity 'hyperferritinemia' named entity 'TNF' named entity 'ferritin' named entity 'therapeutic strategies' named entity 'intermediate hosts' named entity 'GCSF' named entity 'RNAs' named entity 'ferritin' named entity 'COVID-19' named entity 'fever' named entity 'ferritin' named entity 'ferritin' named entity 'sepsis' named entity 'ground-glass opacities' named entity 'COVID' named entity 'IL-7' named entity 'ferritin' named entity 'physiological' named entity 'receptor' named entity 'sepsis' named entity 'JAKs' named entity 'transcription factor' named entity 'COVID' named entity 'septic shock' named entity 'cytokines' named entity 'COVID' named entity 'inflammatory cascade' named entity 'SARS-CoV-2' named entity 'IL-1 receptor antagonist' named entity 'pro-inflammatory cytokine' named entity 'induce the expression' named entity 'CXCL9' named entity 'SARS-CoV-2' named entity 'immunomodulatory' named entity 'biopsies' named entity 'cytokines' named entity 'fever' named entity 'China' named entity 'IL-1β' named entity 'hyperferritinemia' named entity 'fever' named entity 'SJIA' named entity 'enhancer' named entity 'lung' named entity 'ferritin'

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